Results 71 to 80 of about 229,093 (263)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Output Feedback-Based Neural Network Sliding Mode Control for Electro-Hydrostatic Systems with Unknown Uncertainties

Machines
This paper proposes an output feedback-based control for uncertain electro-hydrostatic systems (EHSs) to satisfy high output tracking precision under the influences of unknown mismatched and matched uncertainties and unstructured dynamical behavior.
Tri Dung Dang, Tri Cuong Do, Hoai Vu Anh Truong   +2 more
doaj   +1 more source

Output feedback disturbance rejection control for building structure systems subject seismic excitations

Measurement + Control, 2020
In this paper, the output feedback disturbance rejection control (OFDRC) problem is considered for buildings structures subject seismic excitations.
Qixun Lan, Xiaoguo Zhang, Yajie Li, Jingjing Mu, Weiping Zhu, Huafeng Xu   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Output Feedback Adaptive Stabilization of Uncertain Nonholonomic Systems

Abstract and Applied Analysis, 2014
This paper investigates the problem of output feedback adaptive stabilization control design for a class of nonholonomic chained systems with uncertainties, involving virtual control coefficients, unknown nonlinear parameters, and unknown time delays ...
Yuanyuan Wu, Zicheng Wang, Yuqiang Wu, Qingbo Li   +3 more
doaj   +1 more source

Destabilization by output feedback

Differential and Integral Equations, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hinrichsen, D., Pritchard, A. J.
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Static Output Feedback Control Design for Descriptor Systems

Journal of Control Science and Engineering, 2010
The static output feedback (SOF) synthesis problem for descriptor systems is considered in this paper. LMI-based algorithms are proposed to find potentially structured SOF gains ensuring admissibility and even H∞ performance of the closed-loop system ...
Mohamed Yagoubi
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source