Results 91 to 100 of about 8,360,090 (307)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Prophetic Law in Modern Business: Integration of Humanization, Liberation, and Transcendence in Commercial Contracts

open access: yesBatulis Civil Law Review
Introduction: Economic globalization has significantly influenced the practice of business law, particularly commercial contracts that are increasingly complex, cross-border in nature, and dominated by capitalist interests. Contracts, which ideally serve
Fradhana Putra Disantara   +3 more
doaj   +1 more source

Protecting subspaces by acting on the outside

open access: yes, 2010
Many quantum control tasks aim at manipulating the state of a quantum mechanical system within a finite subspace of states. However, couplings to the outside are often inevitable.
Almut Beige   +11 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Debate: Inside or Outside the Democratic Party [PDF]

open access: yes, 1994
[Excerpt] Since the New Deal, the dominant political strategy of American labor has been to work within the Democratic Party for legislative and other political aims.
Fletcher, Jr., Bill
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

From outside of ethics: Moss, Sarah. Probabilistic Knowledge [PDF]

open access: yes, 2019
Book Review published in the From Outside of Ethics section of Ethics: An International Journal of Social, Political, and Legal Philosophy. Moss, Sarah. Probabilistic Knowledge. Oxford: Oxford University Press, 2018. Pp. 288. $54.00 (cloth)
Smartt, Timothy
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Promoting Student Engagement Through a Change of Scenery

open access: yesAraştırma Temelli Etkinlik Dergisi
Promoting student engagement by changing the environment can effectively refresh minds, stimulate creativity, and increase focus. A learning-centred approach works best when teaching creative arts, but space and creativity are imperative to move around.
Maryna Hattingh
doaj  

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