Results 81 to 90 of about 8,360,090 (307)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Breach of Contract in Digital Transactions on the Itemku Platform: A Case Study of Consumer Rights Violations in Streaming Subscription Services

Batulis Civil Law Review
Introduction: This article examines the issue of breach of contract in digital transactions on the Itemku platform, focusing on consumer rights violations in streaming subscription services.
Fernando Tantaru, Valentino Dinatra Soplantina   +1 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Default in Online Lending: A Legal Review of Standard Clauses and Consumer Protection Against Breach of Contract Claims

Pattimura Legal Journal
Introduction: This article examines the legal challenges surrounding Default (failure to repay) in online lending agreements dominated by standard clauses.
Fernando Tantaru, Valentino Dinatra Soplantila   +1 more
doaj   +1 more source

A Life Outside

Annual Review of Marine Science
How do the morphologies of organisms affect their physical interactions with the environment and other organisms? My research in marine systems couples field studies of the physical habitats, life history strategies, and ecological interactions of organisms with laboratory analyses of their biomechanics.
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

"Outside and In: Hegel on natural history" [PDF]

, 2011
The relation between nature and spirit in Hegel is not as simple as slogans such as "nature has no history" or a simple interior/exterior dichotonmy would ...
Kolb, David
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Learning and Development Program’s Admission Requirements and Student Engagement as Success Determinants in Accountancy

SAGE Open
This study focuses on the admission criteria of a bachelor of accountancy (BAcc) degree program as one of many factors influencing students’ success in graduating in the regulated time frames.
Onesmus Ayaya, Michael Kgorompe Moswatsi
doaj   +1 more source

Outside-in disk evolution in the LMC

, 2008
From the analysis of the color-magnitude diagrams and color functions of four wide LMC fields located from ~2 to 6 kpc from the kinematic center of the LMC we present evidence that, while the oldest population is coeval in all fields, the age of the ...
Abadi, Aparicio, Barker, Bernard, Brook, Carme Gallart, Carrera, Eduardo Hardy, Frederic Pont, Gallart, Gallart, Hidalgo, Holtzman, Ingrid P. Meschin, Muñoz-Mateos, Noël, Noël, Olsen, Peter B. Stetson, Pietrinferni, Roškar, Schlegel, Skillman, Taylor, van der Marel, van der Marel, Vansevičius   +26 more
core   +1 more source