Results 81 to 90 of about 3,485 (310)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Research on the Dimensional Accuracy Measurement Method of Cylindrical Spun Parts Based on Machine Vision

MATEC Web of Conferences, 2018
A new method for measuring the dimensional accuracy of the cylindrical spun parts based on machine vision was proposed to overcome the artificial deviation and low efficiency of manual measurement. The image acquisition system of machine vision was built
Gangfeng Xiao, Xingwei Zhong, Weixian Shen, Qinxiang Xia, Weiping Chen   +4 more
doaj   +1 more source

Experimental Investigation of Process Parameters in Drilling LM25 Composites Coated with Multi Wall Carbon Nano Tubes Using Sonication Process

Archives of Metallurgy and Materials, 2017
Aluminium based metal matrix composites are widely used in automobile components such as cardan shaft of Chevrolet corvette, disc brake and engine push rod. In this experiment a Hybrid Metal Matrix Composites (HMMC) are fabricated and drilled.
Sangeetha M., Prakash S.
doaj   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Surface roughness modeling of CBN hard steel turning [PDF]

, 2018
Study in the paper investigate the influence of the cutting conditions parameters on surface roughness parameters during turning of hard steel with cubic boron nitrite cutting tool insert. For the modeling of surface roughness parameters was used central
Ješić, D., Kovač, P., Nedic, B., Rodić, D., Savković, B., Taric, M.   +5 more
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A Monte Carlo investigation of thrust imbalance of solid rocket motor pairs [PDF]

A technique is described for theoretical, statistical evaluation of the thrust imbalance of pairs of solid-propellant rocket motors (SRMs) firing in parallel.
Foster, W. A., Jr., Johnson, J. S., Jr., Sforzini, R. H.   +2 more
core   +1 more source

Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual‐Immunotherapy Against Bladder Cancer

Advanced Science, EarlyView.
The novel intravesical delivery system exhibits GSH‐responsive drug release, enabling a synergistic therapeutic strategy that combines ferroptosis, ICD and PTT. ABSTRACT Ferroptosis, a newly recognized form of regulated cell death, has emerged as a promising strategy in cancer therapy.
Xiaojian Xu, Rui Liang, Anguo Zhao, Jun Zhang, Rongkang Li, Yang Liu, Dashi Deng, Qi Zhuang, Lisha Liu, Lei Peng, Miao Li, Xuedong Wei, Yuhua Huang, Shaohua Zhang, Liang Cheng, Jianquan Hou   +15 more
wiley   +1 more source

Study on the effect of geometry and material property on collapse pressure of a helical steam generator tube under external pressure

Nuclear Engineering and Technology
In this paper, a numerical study was conducted to analyze the effect of the geometry (tube thickness, ovality, and helical diameter) and material properties of once through steam generator tubes subjected to external pressure on collapse pressure.
Gyo-Geun Youn, Kwanghyun Ahn, Myeong-Woo Lee   +2 more
doaj   +1 more source

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population.

PLoS ONE, 2017
PurposeTo identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons.Patients and methodsMedical records of NTG patients with asymmetric and symmetric VF losses were ...
Eun Jung Lee, Jong Chul Han, Changwon Kee   +2 more
doaj   +1 more source