Results 91 to 100 of about 769,731 (345)
Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceBRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers [PDF]
, 2016 Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer.Agnarsson, Bjarni A., Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Antoniou, Antonis C., Bandera, Elisa V., Banerjee, Susana, Barile, Monica, Barrowdale, Daniel, Beckman, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Berchuck, Andrew, Bjorge, Line, Blomqvist, Carl, Bogdanova, Natalia V., Bojesen, Stig E., Bolla, Manjeet K., Borg, Ake, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Bruinsma, Fiona, Brunet, Joan, Brüning, Thomas, Burwinkel, Barbara, Butterbach, Katja, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Campbell, Ian G., Cannioto, Rikki, Castillo, Danielle, Chan, Salina B., Chang-Claude, Jenny, Chenevix-Trench, Georgia, Claes, Kathleen B. M., Collavoli, Anita, Cook, Linda S., Couch, Fergus J., Cox, Angela, Cramer, Daniel, Cross, Simon S., Cunningham, Julie M., Czene, Kamila, Daly, Mary B., Damiola, Francesca, Darabi, Hatef, de la Hoya, Miguel, Dennis, Joe, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A., Domchek, Susan M., Dorfling, Cecilia M., Dunning, Alison M., Dörk, Thilo, Easton, Douglas F., Eccles, Diana M., Ellis, Steve, Eunjung, Lee, Fasching, Peter A., Feng, Bingjian, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Foretova, Lenka, Fostira, Florentia, Friedman, Eitan, Frost, Debra, Ganz, Patricia N., Gao, Yu-Tang, Garber, Judy, García-Closas, Montserrat, Gayther, Simon, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., González-Neira, Anna, Goode, Ellen L., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A., Hall, Per, Hallberg, Emily, Hamann, Ute, Hansen, Thomas V. O., Hart, Steven N., Healey, Sue, Heitz, Florian, Henderson, Brian E., Henriksson, Karin, Hildebrant, Michelle A. T., Hogdall, Claus, Hogdall, Estrid, Hogervorst, Frans B. L., Hopper, John L., Hosono, Satoyo, Hulick, Peter J., Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allen, John, Esther M., Johnson, Nichola, Jones, Michael, Kabisch, Maria, Karlan, Beth Y., Khan, Sofia, Kiemeney, Lambertus A., Kjaer, Susanne K., Knight, Julia A., Konstantopoulou, Irene, Koppert, Linetta B., Kosma, Veli-Matti, Kristensen, Vessela, Kupryjanczyk, Jolanta, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Le, Nhu, Lester, Jenny, Levine, Douglas, Li, Jingmei, Liang, Dong, Lindblom, Annika, Loud, Jennifer T., Lu, Karen H., Lubinski, Jan, Mai, Phuong L., Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Marme, Frederik, Massuger, Leon F. A. G., Matsuo, Keitaro, Maugard, Christine, Mazoyer, Sylvie, McGuffog, Lesley, McNeish, Iain, Meeks, Huong D., Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Milne, Roger L., Modugno, Francesmary, Moes-Sosnowska, Joanna, Montagna, Marco, Monteiro, Alvaro N. A., Moysich, Kirsten B., Narod, Steven, Nathanson, Katherine L., Ness, Roberta, Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Nussbaum, Robert L., Offit, Kenneth, Olah, Edith, Oliani, Cristina, Olopade, Olufunmilayo I., Olson, Janet E., Olson, Sara H., Osorio, Ana, Park, Sue K., Pasini, Barbara J., Pearce, Leigh, Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Pejovic, Tanja, Pelttari, Liisa M., Peterlongo, Paolo, Pharoah, Paul D. P., Phelan, Catherine M., Piedmonte, Marion, Poole, Elizabeth M., Pylkäs, Katri, Radice, Paolo, Ramus, Susan J., Rantala, Johanna, Rappaport-Feurhauser, Christine, Rennert, Gad, Riboli, Elio, Risch, Harvey, Robson, Mark, Rossing, Mary Anne, Rudolph, Anja, Salvesen, Helga B., Sawyer, Elinor J., Schildkraut, Joellen, Schmidt, Marjanka K., Schoemaker, Minouk J., Segura, Pedro Perez, Senter, Leigha, Shah, Mitul, Shimelis, Hermela, Siddiquil, Nadeem, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sinilnikova, Olga M., Slager, Susan, Song, Honglin, Soucy, Penny, Southey, Melissa C., Spurdle, Amanda B., Stoppa-Lyonnet, Dominique, Swerdlow, Anthony, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., Terry, Mary Beth, Tesoriero, Andrea, Thomassen, Mads, Thompson, Pamela J., Tihomirova, Laima, Tischkowitz, Marc, Tollenaar, Robert A. E. M., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Tucker, Kathy, Tung, Nadine, Tworoger, Shelley S., van der Ouweland, Ans M. W., Van Maerken, Tom, van Rensburg, Elizabeth J., Varon-Mateeva, Raymonda, Viel, Alessandra, Wang, Qin, Wappenschmidt, Barbara, Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittermore, Alice S., Winqvist, Robert, Woo, Yin Ling, Wu, Anna, Yoon, Sook-Yee, Zheng, Wei, Öfverholm, Anna +252 morecore +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceA mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer
Nature Communications, 2019 Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient survival based Haonan Lu, Mubarik Arshad, Andrew Thornton, Giacomo Avesani, Paula Cunnea, Ed Curry, Fahdi Kanavati, Jack Liang, Katherine Nixon, Sophie T. Williams, Mona Ali Hassan, David D. L. Bowtell, Hani Gabra, Christina Fotopoulou, Andrea Rockall, Eric O. Aboagye +15 moredoaj +1 more sourceCharacterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C
Cells, 2020 Ovarian clear cell carcinoma (OCCC) is a rare subtype of gynecological cancer for which well-characterized and authenticated model systems are scarce. We provide an extensive characterization of ‘105C’, a cell line generated from an adenocarcinoma of the Bart Kolendowski, Yudith Ramos Valdes, Hal Hirte, Hiroaki Itamochi, Wonjae Lee, Mark Carey, Trevor G. Shepherd, Gabriel E. DiMattia +7 moredoaj +1 more sourceCCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more source
