Results 151 to 160 of about 755,388 (347)
DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer
Advanced Science, EarlyView.In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger +20 morewiley +1 more sourceInhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers
, 2020 Yao Shen, Jiaxin Hong, Ryoichi Asaka, Shiho Asaka, Fang‐Chi Hsu, Yohan Suryo Rahmanto, Jin-Gyoung Jung, Yu-Wei Chen, Ting‐Tai Yen, Alicja Tomaszewski, Cissy Zhang, Nabeel Attarwala, Angelo M. De Marzo, Ben Davidson, Chi-Mu Chuang, Xi Chen, Stéphanie Gaillard, Anne Le, Ie‐Ming Shih, Tian‐Li Wang +19 moreopenalex +2 more sourcesThe MYBL2–CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages [PDF]
, 2023 Baoyue Pan, Ting Wan, Yun Zhou, Shuting Huang, Linjing Yuan, Yinan Jiang, Xiaojing Zheng, Pingping Liu, Huiling Xiang, Mingxiu Ju, Rongzhen Luo, Wei‐Hua Jia, Chunyan Lan, Jundong Li, Min Zheng +14 moreopenalex +1 more sourceRELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target
Advanced Science, EarlyView.Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li +17 morewiley +1 more sourceDiagnostic routes and time intervals for ovarian cancer in nine international jurisdictions; findings from the International Cancer Benchmarking Partnership (ICBP) [PDF]
, 2022 Usha Menon, David Weller, Alina Zalounina Falborg, Henry Jensen, John Butler, Andriana Barisic, Anne Kari Knudsen, Rebecca J. Bergin, David Brewster, Victoria Cairnduff, Evangelia Ourania Fourkala, Anna Gavin, Eva Grunfeld, Beth Harland, Jatinderpal Kalsi, Rebecca‐Jane Law, Yulan Lin, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Irene Reguilon, Charlotte Lynch, Peter Vedsted, Andriana Barisic, Anna Gavin, Breann Hawryluk, Chantelle Anandan, Conan Donnelly, Henry Jensen, Jackie Boylan, Jacqueline Kelly, Kerry Moore, Maria Rejmyr Davis, Martin Malmberg, Mats Lambe, Oliver Bucher, Peter Vedsted, Rebecca J. Bergin, Sigrun Saur Almberg, Therese Kearney, Tindie Kalsi, Vicky Hammersley +42 moreopenalex +1 more sourceType II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release
Advanced Science, EarlyView.The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu +17 morewiley +1 more sourceModeling the growth of multicellular cancer spheroids in a\ud
bioengineered 3D microenvironment and their treatment with an\ud
anti-cancer drug [PDF]
, 2010 A critical step in the dissemination of ovarian cancer cells is the formation of multicellular spheroids from cells shed from the primary tumor.Byrne, H. M., Clements, J. A., Flegg, J. A., Hall, C. L., Hutmacher, D. W., Loessner, D., McElwain, D. L. S., Moroney, T. J. +7 morecore An Integrated Approach for the Early Detection of Endometrial and Ovarian Cancers (Screenwide Study): Rationale, Study Design and Pilot Study [PDF]
, 2022 Paula Peremiquel‐Trillas, Sònia Paytubi, Beatriz Pelegrina, Jon Frias‐Gomez, Álvaro Carmona, José Manuel Martínez, Javier de Francisco, Yolanda Benavente, Marc Barahona, Ferran Briansó, Júlia Canet-Hermida, Víctor Manuel Jiménez-Cano, August Vidal, Alba Zanca, Núria Baixeras, A. Rodríguez, Sergi Fernández-González, Núria Dueñas, Laura Càrdenas, Àlvaro Aytés, Ilaria Bianchi, Miguel Ángel Pavón, Jaume Reventós, Gabriel Capellá, David Gómez, Mireia Díaz, Jordi Ponce, Joan Brunet, Xavier Matías‐Guiu, F. Xavier Bosch, Sílvia de Sanjosé, Laia Alemany, Marta Pineda, Fátima Marín, Laura Costas +34 moreopenalex +1 more source
