Results 211 to 220 of about 5,337,944 (374)
Transcript Identification Using Arrayed Hydrogels With TrapFISH
Advanced Materials Technologies, EarlyView.TrapFISH is a novel method for high‐throughput single‐cell transcriptomics. It embeds cells in hyaluronic acid hydrogel beads and uses probe hybridization to quantify custom gene panels. By arraying hydrogels in microfluidic devices, cell barcoding is removed, enhancing scalability for studying cellular heterogeneity and rare cell states by targeting ...
David B. Morse +5 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.A miniaturized microfluidic device is 3D printed via two‐photon polymerization and used for the droplet‐based microfluidic synthesis of nanogels for controlled drug delivery purposes. Tuning the fluid flow parameters, the microfluidic system enables the modulation of nanogel size and properties, preserving an extremely low polydispersity, beyond the ...
Vladimir Matining +8 more
wiley +1 more source
Progress in Surface Plasmon and Other Resonance Biosensors for Biomedical Applications
Advanced Materials Technologies, EarlyView.This is the shortened version: Recent advancements in surface plasmon resonance and other optical resonance biosensors for biomedical applications are presented. Advanced sensing strategies are examined for the detection of diverse analytes, integration of nanomaterials and machine learning, and emerging nonplasmonic modes like guided mode resonance ...
Faten Bashar Kamal Eddin +8 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar +13 more
wiley +1 more source
Digital Bioassays on the Slipchip Microfluidic Devices
Advanced Sensor Research, EarlyView.This review summarizes recent advances in SlipChip‐based digital bioassays, highlighting their simple “load and slip” operation for fluid partitioning which eliminate the need for sophisticated fluidic systems. Applications include digital nucleic acid analysis, digital protein analysis and single‐cell analysis, demonstrating the platform‘s potential ...
Qingqing Luo +5 more
wiley +1 more source
Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models
STAR ProtocolsSummary: Three-dimensional (3D) ex vivo cultures allow the study of cancer progression and drug resistance mechanisms. Here, we present a protocol for measuring on-target drug sensitivity in a scaffold-free 3D culture system through quantification of ...
Kathrin B. Labrosse +7 more
doaj
p53 gene mutations and protein accumulation in human ovarian cancer. [PDF]
, 1993 Jolanta Kupryjańczyk +6 more
openalex +1 more source
Advanced Therapeutics, EarlyView.This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen +2 more
wiley +1 more source