Results 251 to 260 of about 5,260,709 (398)

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng   +21 more
wiley   +1 more source

Protracted oral etoposide in epithelial ovarian cancer: a phase II study in patients with relapsed or platinum-resistant disease [PDF]

, 1994
Michel Seymour, JL Mansi, CJ Gallagher, ME Gore, PG Harper, TRJ Evans, PM Edmonds, ML Slevin   +7 more
openalex   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

New England Journal of Medicine, 2018
W. V. van Driel, S. Koole, K. Sikorska, J. H. Schagen van Leeuwen, H. Schreuder, R. Hermans, I. D. de Hingh, J. van der Velden, H. Arts, L. Massuger, A. Aalbers, V. Verwaal, J. Kieffer, Koen K. van de Vijver, H. van Tinteren, N. Aaronson, G. Sonke   +16 more
semanticscholar   +1 more source

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional Runx2 (exon 6‐exclusive) isoforms to reinforce osteoblast differentiation.
Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei   +9 more
wiley   +1 more source

The Role of microRNA in the Prognosis and Diagnosis of Ovarian Cancer. [PDF]

Int J Mol Sci
Kozłowski M, Borzyszkowska D, Golara A, Lubikowski J, Cymbaluk-Płoska A.   +4 more
europepmc   +1 more source

Family History of Breast, Ovarian and Endometrial Cancer and Risk of Breast Cancer [PDF]

, 1993
Fabio Parazzini, Carlo La Vecchia, Eva Negri, Silvia Franceschi, Luca Tozzi   +4 more
openalex   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source

Latest Update on lncRNA in Epithelial Ovarian Cancer-A Scoping Review. [PDF]

Cells
Kwas K, Szubert M, Wilczyński JR.
europepmc   +1 more source

Therapy in Stage I ovarian cancer

, 1981
A.J. Dembo, R. S. Bush, G. de Boer
openalex   +1 more source