Results 281 to 290 of about 5,436,787 (348)

Advances in the use of exosomes for the diagnosis and treatment of ovarian cancer. [PDF]

World J Surg Oncol
Chen J, Tan Q.
europepmc   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer. [PDF]

Signal Transduct Target Ther
Bley N, Rausch A, Müller S, Simon T, Glaß M, Misiak D, Schian L, Peters LM, Dipto M, Hmedat A, Busch B, Schott A, Lederer M, Wedler A, Rolnik RB, Elrewany H, Ghazy E, Sippl W, Vetter M, Wallwiener M, Hüttelmaier S.   +20 more
europepmc   +1 more source

Anionic Liposomes as Optimal Membrane Fusion Carriers Enabling in Situ Multiplexed Detection of Extracellular Vesicle MicroRNAs

Advanced Science, EarlyView.
A novel strategy for in situ multiplexed miRNA analysis of plasma extracellular vesicles (EValarm) has been developed. EValarm enables straightforward detection of different extracellular vesicle miRNAs from plasma samples through systematic screening of liposome surface charges, without requiring complex pretreatment steps, and achieves satisfactory ...
Jing‐Yuan Ma, Xiao Wang, Yuhan Cai, Guancheng Wang, Mingze Lu, Kaizheng Feng, Ying Zhao, Xue Wu, Xiaoping Zhang, Haoan Wu, Wei Yu, Ming Ma, Zheng Ge, Yu Zhang   +13 more
wiley   +1 more source

Apoptosis of Mesothelial Cells Is Associated with the Pattern of Peritoneal Metastases in Ovarian Cancer. [PDF]

Cancers (Basel)
Maksin K, Nadolna M, Wozniak M, Bocharova T, Jasinski P, Nowicki M, Nowak-Markwitz E, Szubert S.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Fallopian tube lavage sampling towards early detection of pre-invasive ovarian cancer. [PDF]

Clin Transl Med
Seaton M, Harbach S, Oke J, Walker TDJ, Dalton-O'Reilly J, Selley J, Brison DR, Bolton J, Meyer S, Knight D, Edmondson RJ, Schmidt CK.   +11 more
europepmc   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

RNA sequencing in ovarian cancer research: a comprehensive review. [PDF]

J Ovarian Res
Shen F, Li C, Li Y, Shen Y, Han F.
europepmc   +1 more source