Results 61 to 70 of about 2,653,643 (293)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Investigating the impact of NHS based ovarian cancer screening [PDF]
, 2010 the UK ovarian cancer is the fifth most common cancer in females and after uterine cancer, the second most common gynaecological cancer. There were 6,596 new cases diagnosed in the UK in 2006.
Nicholson, S. M.
core +3 more sources
Automatic segmentation of ovarian follicles using deep neural network combined with edge information
Frontiers in Reproductive Health, 2022 Medical ultrasound imaging plays an important role in computer-aided diagnosis systems. In many cases, it is the preferred method of doctors for diagnosing diseases.
Zhong Chen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection [PDF]
, 2010 In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker ...
Brigitte E. Miller +20 more
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Ovarian cancer screening in the general population. [PDF]
, 2007 Despite significant improvements in therapy, ovarian cancer continues to be a leading cause of death amongst women with gynaecological malignancies. Advanced stage at diagnosis is thought to be a major contributor to mortality.
Menon, U., Menon, Usha Dr
core
ANALYSIS OF OVARIAN DISEASES USING ULTRASOUND IMAGES [PDF]
, 2017 Ovarian disease is the most common disease occurring in female reproductive organs. The premature recognition and action needed for diagnosis the disease to avoid infertility or cancer to them.
Rajan, S. Palanivel +3 more
core +1 more source
BiomoleculesNerve Growth Factor (NGF), a member of the neurotrophin family, is currently regarded as a key regulator of ovarian physiology beyond its well-known neurotrophic functions.
Massimo Aloisi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source