Results 131 to 140 of about 215,664 (299)

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

open access: yesAdvanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma   +10 more
wiley   +1 more source

Dissecting the molecular landscape of synchronous endometrial and ovarian carcinoma and the aetiology of endometriosis-associated ovarian carcinoma [PDF]

open access: yes
Epithelial ovarian cancer, or ovarian carcinoma, is a group of diseases which can be characterised by histopathological subtype (‘histotype’). Ovarian endometrioid and ovarian clear cell carcinoma each account for 10% of ovarian carcinoma cases; these ...
Southworth, Emily Christine
core   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

open access: yesAdvanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao   +28 more
wiley   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

open access: yesAdvanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li   +4 more
wiley   +1 more source

Host cell factors in ovarian cancer influencing efficacy of oncolytic aenovirus dl922-947

open access: yes, 2010
PhDAdenoviral gene therapy holds great potential for cancer treatment, but is limited by a lack of efficient vectors. dl922-947, an E1A CR2-deleted adenovirus, replicates selectively within and lyses cancer cells.
Flak, Magdalena Barbara
core  

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li   +10 more
wiley   +1 more source

Premature ovarian insufficiency: When ovaries retire early

open access: yes
Introduction: Premature ovarian insufficiency (POI) refers to loss of ovarian activity before the age 40 years. POI has significant detrimental effects on health (infertility, cardiovascular diseases, type 2 diabetes, reduced bone density, dementia ...
Tze Tein Yong   +8 more
core   +1 more source

Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults

open access: yes, 2015
Copyright © 2015 Elsevier Ltd. All rights reserved.Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment..
Mitchell, Rod T   +5 more
core   +1 more source

Study concerning the prevalence of ovarian diseases in Aberdeen angus cows

open access: yes, 2019
Infertility in cows is one of the major problems with great economic implications. The purpose of this study was to identify by global and individual gynecological investigation major ovarian diseases and to determinate their incidence in the relation ...
Blaga Petrean, Anamaria   +6 more
core   +1 more source

Incidence and mortality of ovarian cancer among permanent residents in the Former Luwan District of Shanghai between 2002 and 2011

open access: yesZhongguo aizheng zazhi, 2018
Background and purpose: Ovarian cancer is one of the most lethal gynecologic cancers worldwide. This study aimed to analyze the incidence and mortality of ovarian cancer among local residents in the Former Luwan District in Shanghai from Jan. 2002 to Dec.
王烨菁
doaj  

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