Results 111 to 120 of about 307,578 (312)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Oogenesis and germinal bed morphology of the brown anole (A. sagrei)

Developmental Dynamics, EarlyView.
Abstract Background The brown anole is a model species of the genus Anolis, a squamate (encompassing lizards and snakes) group widely studied in evolutionary, behavioral, and developmental biology. Full genome annotation, the establishment of gene editing techniques, and comprehensive description of reproductive tract morphology and embryogenesis in ...
Bonnie K. Kircher, Antonia Weberling, Erin J. Vance, Natalia A. Shylo, Katherine Starr, Zoe B. Griffin, Hannah Wilson, Melainia McClain, Florian Hollfelder, Suzannah A. Williams, Thomas J. Sanger, Richard R. Behringer, Paul A. Trainor   +12 more
wiley   +1 more source

The physiology and clinical utility of anti-Müllerian hormone in women [PDF]

, 2014
This paper is a summary of the presentations at the ESHRE campus workshop on AMH in Lille, France, on 10–11 May 2012, with literature update until September 2013.
Kelsey, Tom W, Broekmans, F., Kelsey, Tom W., Visser, J. A., La Marca, A., Griesinger, Georg, Visser, J.A., Nelson, S.M., Lambalk, Cornelius, Dewailly, Didier, Mason, Helen, Nelson, SM, Visser, Jenny A.; id_orcid, Wallace, W Hamish, Griesinger, G, Andersen, CY, Balen, Adam, Visser, Jenny A, Kelsey, T.W., Wallace, W. Hamish, Wallace, W. H., Visser, Jenny; id_orcid, Hamish Wallace, W., Wallace, WH, Andersen, Claus Yding, Nelson, Scott M, Anderson, Richard A, LA MARCA , Antonio, Mason, H, Anderson, R.A., Lambalk, C., La Marca, A, Visser, Jenny A., Broekmans, F, Fanchin, R, Anderson, R. A., Anderson, Richard A., Balen, A., Griesinger, G., Andersen, C.Y., Nelson, Scott M., Dilaver, Nafi, Wallace, W.H., Fanchin, Renato, Mason, H., Dilaver, N, Anderson, RA, Balen, A, La Marca, Antonio, Dewailly, D, Kelsey, TW, Broekmans, Frank, Andersen, C. Y., Lambalk, C.B., Kelsey, T. W., Dewailly, D., Fanchin, R., Dilaver, N., Lambalk, C   +58 more
core   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression

Cell & Bioscience, 2017
Background Mammalian folliculogenesis, maturation of the ovarian follicles, require both growth factors derived from oocyte and surrounding cells, including stromal cells.
Shu Tan, Boya Feng, Mingzhu Yin, Huanjiao Jenny Zhou, Ge Lou, Weidong Ji, Yonghao Li, Wang Min   +7 more
doaj   +1 more source

Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults [PDF]

, 2015
Copyright © 2015 Elsevier Ltd. All rights reserved.Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment..
Mitchell, Rod T, Anderson, Richard A, Spears, Norah, Wallace, W Hamish B, Kelsey, Thomas W, Telfer, Evelyn E   +5 more
core   +1 more source

Age, embryo donor status, and insemination with chilled semen all predispose to persistent breeding‐induced endometritis in warmblood mares

Equine Veterinary Journal, EarlyView.
Abstract Background Persistent breeding‐induced endometritis (PBIE) is a common reason for mares failing to establish pregnancy. Objective To examine the hypothesis that advancing mare age and embryo donor status predispose to PBIE and compromise fertility.
Tom Stout, Rik Serrarens, Bart Leemans, Anthony Claes   +3 more
wiley   +1 more source

Veterinarian and breeder perspectives surrounding ovum pick‐up and intracytoplasmic sperm injection in mares: A survey study

Equine Veterinary Journal, EarlyView.
Abstract Background There is an ethical debate about the application of ovum pick‐up (OPU) and intracytoplasmic sperm injection (ICSI) in mares. Objectives To survey the opinions of equine veterinarians and breeders of sport horses on the ethics of using OPU–ICSI in mares. Study Design Cross‐sectional descriptive study.
Niamh Lewis, Jannie Spanner, Peter Daels, Juan Cuervo Arango, Monica Morganti, Pouya Dini, Kate Allen, Siobhan Mullan   +7 more
wiley   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source