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Granulosa Cells: Central Regulators of Female Fertility
EndocrinesBackground: Granulosa cells are somatic cells within the ovarian follicle. As the primary site of estradiol production, they are critical regulators of several aspects of female reproduction.
Luis Fernando Schütz +1 more
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Interaction between growing oocytes and granulosa cells in vitro [PDF]
Reproductive Medicine and Biology, 2020 Background Oocyte growth is accompanied by follicular development in mammalian ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15), knowledge of the bidirectional ...
Md Hasanur Alam, Takashi Miyano
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PLoS ONE, 2015 In studies using isolated ovarian granulosa and thecal cells it is important to assess the degree of cross contamination. Marker genes commonly used for granulosa cells include FSHR, CYP19A1 and AMH while CYP17A1 and INSL3 are used for thecal cells.
Nicholas Hatzirodos +3 more
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Bioencapsulation of Oocytes and Granulosa Cells
, 2023 A protocol for the encapsulation in sodium alginate of granulosa cells in primary culture and coculture of oocyte-cumulus complexes is reported. Sodium alginate forms strong gels when jellified with barium ions, allowing the self-organization of cells into a 3D structure.
Faustini, Massimo +4 more
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Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration [PDF]
PeerJ, 2021 Granulosa cells play an essential physiological role in mediating the follicle development and survival or apoptosis of granulosa cells dictate the follicle development or atresia.
Shujuan Wang +4 more
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OAZ1 knockdown enhances viability and inhibits ER and LHR transcriptions of granulosa cells in geese. [PDF]
PLoS ONE, 2017 An increasing number of studies suggest that ornithine decarboxylase antizyme 1 (OAZ1), which is regarded as a tumor suppressor gene, regulates follicular development, ovulation, and steroidogenesis.
Bo Kang +5 more
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PRMT5 regulates ovarian follicle development by facilitating Wt1 translation
eLife, 2021 Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric dimethylation of arginine. Here, we found that PRMT5 was expressed at high level in ovarian granulosa cells of growing follicles.
Min Chen +8 more
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Journal of Ovarian Research, 2020 Background The complex regulatory mechanism involved in ovarian follicular development is not completely understood. Neuronal neuropeptide Y (NPY) is involved in the regulation of feeding behavior, energy homeostasis, and reproduction behavior, while its
Yoko Urata +4 more
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Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice. [PDF]
PLoS ONE, 2018 It has been known that EGF-like factor secreted from LH-stimulated granuloma cells acts on granulosa cells and cumulus cells to induce ovulation process.
Hiroya Kitasaka +5 more
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Data in Brief, 2020 Disruption of estrogen receptor beta (ESR2) dysregulates granulosa cell genes essential for follicle maturation and ovulation. The datasets presented in this article depict gonadotropin-induced genes, which are differentially expressed in Esr2-null rat ...
V. Praveen Chakravarthi +4 more
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