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Granulosa cell tumor patients presenting with acute abdomen: a case series [PDF]

Gynecologic Oncology Reports
Objective: To highlight the unique clinical presentation of acute abdomen in granulosa cell tumor patients. Methods: In a multicenter cohort study of adult-type granulosa cell tumors, women presenting with an acute abdomen at diagnosis were identified ...
Geertruid J. Brink, Jolijn W. Groeneweg, Ariane A. Sickinghe, Christianne A.R. Lok, Hans W. Nijman, Jurgen M.J. Piek, Ward Hofhuis, Eva Maria Roes, Luc R.C.W. van Lonkhuijzen, Cor D. de Kroon, Eelke H. Gort, Petronella O. Witteveen, Ronald P. Zweemer   +12 more
doaj   +2 more sources

Intrinsic differences in mTOR activity mediates lineage-specific responses to cyclophosphamide in mouse and human granulosa cells

Journal of Ovarian Research
Background Cyclophosphamide (CTX) often induces oocyte and granulosa cell injury, leading to fertility loss in young female cancer survivors. Deciphering the mechanisms underlying follicular cell injury could offer novel insights into fertility ...
Shiqian Xu, Yerong Ma, Yinli Zhang, Hanqi Ying, Xiaomei Tong, Weijie Yang, Yibin Pan, Yan Rong, Yangyang Dai, Songying Zhang, Peidong Han   +10 more
doaj   +1 more source

Granulosa cell tumor of the ovary: a clinicopathological study of six cases

Journal of Pathology of Nepal, 2011
Background: Ovarian granulosa cell tumors are rare malignant neoplasms that originate from the sexcord stromal cells of the ovary. The study aims to collate data of all granulosa cell tumors diagnosed in Tribhuvan University Teaching Hospital over the ...
RC Adhikari, A Jha, G Shayami
doaj   +1 more source

Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p

Biological Research, 2023
Background The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells.
Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin, Hongliang Tang   +8 more
doaj   +1 more source

4-Aminopyridine Decreases Progesterone Production by Porcine Granulosa Cells

Reproductive Biology and Endocrinology, 2003
Background Ion channels occur as large families of related genes with cell-specific expression patterns. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. The purpose of this study was to determine the
Mitchell Brianna M, Mason Diane E, von Stein Fred B, Ganta Suhasini, Li Yan, Freeman Lisa C   +5 more
doaj   +1 more source

Collision Tumor of the Ovary: Adult Granulosa Cell Tumor and Mesonephric-like Adenocarcinoma

Diagnostics
Collision tumors of the ovaries are rare, with only a few reports in the literature. Adult granulosa cell tumors are a relatively common primary tumor component of previously reported collision tumors.
Yujin Lee, Mohammad Rizwan Alam, Jin-Hwi Kim, Chan Joo Kim, Su Lim Lee, Kwangil Yim   +5 more
doaj   +1 more source

Ligand-based directed differentiation to produce granulosa-like cells expressing steroidogenic enzyme genes

Stem Cell Research
The ovarian granulosa cells are responsible for producing hormones and supporting oocytes through maturation and meiotic resumption. There is a need to generate granulosa-like cells (GLCs) from human induced pluripotent stem cells (hiPSCs) to better ...
Hana Kubo, Lina Lu, Maya VanZanten, Janavi Thyagraj, Diane C. Saunders, Ruli Gao, Monica M. Laronda   +6 more
doaj   +1 more source

The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia

Journal of Animal Science and Biotechnology
Background Follicular atresia significantly impairs female fertility and hastens reproductive senescence. Apoptosis of granulosa cells is the primary cause of follicular atresia.
Hao Wu, Yingxue Han, Jikang Liu, Rong Zhao, Shizhen Dai, Yajun Guo, Nan Li, Feng Yang, Shenming Zeng   +8 more
doaj   +1 more source

Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells

Cells
Necroptosis and dysfunction of ovarian granulosa cells are major contributors to follicular atresia and reduced fertility in cattle, processes that are closely associated with endoplasmic reticulum stress (ERS).
Hongjie Wang, Yi Fang, Lei Huang, Xu Yang, Xin Ma, Yang Lyu, Guo Jing, He Ding, Hongyu Liu, Wenfa Lyu   +9 more
doaj   +1 more source

Granulosa cell tumor of ovary: A clinicopathological study of four cases with brief review of literature

Journal of Mid-Life Health, 2014
Introduction: Adult granulosa cell tumor (GCT) is a rare ovarian malignancy having good prognosis in comparison with other epithelial tumors. The study aims to collect data of all granulosa cell tumors diagnosed in ESIC Medical College & PGIMSR ...
B R Vani, K Geethamala, R L Geetha, Murthy V Srinivasa   +3 more
doaj   +1 more source