The anti-epileptic drug Valproic Acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro [PDF]
, 2012 Valproic acid (VPA) is used widely to treat epilepsy and bipolar disorder. Women undergoing VPA treatment reportedly have an increased incidence of polycystic ovarian syndrome (PCOS)-like symptoms including hyperandrogenism and oligo- or amenorrhoea.
Knight, PG +19 more
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Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review [PDF]
Journal of Pathology and Translational Medicine, 2018 Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children ...
Nu Ri Jang +5 more
doaj +1 more source
Lipid, fatty acid and protein utilization during lecithotrophic larval development of Lithodes santolla (Molina) and Paralomis granulosa (Jacquinot) [PDF]
, 2003 During the larval development of the subantarctic king crab, Lithodes santolla, and stone crab, Paralomis granulosa, we compared changes in the carbon, fatty acid and protein contents of larvae reared under constant conditions from hatching to ...
Kattner, G. +13 more
core +1 more source
, 2009 For decades, scientists have thought that female mammals are born with a lifetime supply of oocytes in the ovary, irreversibly destined to decline after birth.
Tomaszczuk-Kossowska, Katarzyna
core +1 more source
Journal of Ovarian Research, 2017 Background Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable indolent growth with malignant potential and late recurrence. Approximately 95% are of adult type. Recent molecular studies have characterized the
Wen-Chung Wang +2 more
doaj +1 more source
First year growth in the lithodids Lithodes santolla and Paralomis granulosa reared at different temperatures [PDF]
, 2005 The southern king crab, Lithodes santolla Molina, and stone crab, Paralomis granulosa Jacquinot, inhabit the cold-temperate waters of southernmost South America (southern Chile and Argentina), where stocks of both species are endangered by overfishing ...
Calcagno, J.A. +15 more
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Reproductive Biology and Endocrinology, 2003 Oocyte control of granulosa and theca cell function may be mediated by several growth factors via a local feedback loop(s) between these cell types. This study examined both the role of oocyte-secreted factors on granulosa and thecal cells, cultured ...
Webb Bob +3 more
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Granulosa cell tumor of the ovary
Cancer Treatment Reviews, 2008 Ovarian granulosa cell tumors (GCTs) are uncommon neoplasms that arise from the sex-cord stromal cells of the ovary. GCTs are characterized by long natural history and their tendency to recur years after the initial diagnosis. They present with symptoms and signs due to estradiol secretion, including vaginal bleeding and precocious puberty ...
Pectasides, D. +2 more
openaire +3 more sources
Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth. [PDF]
FASEB JWorking model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Marie C +8 more
europepmc +2 more sources
Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells : Implications for luteolysis [PDF]
, 2009 The human LH receptor (LHR) plays a key role in luteal function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin.
Dickinson, Rachel E +5 more
core +1 more source