The anti-epileptic drug Valproic Acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro [PDF]
Valproic acid (VPA) is used widely to treat epilepsy and bipolar disorder. Women undergoing VPA treatment reportedly have an increased incidence of polycystic ovarian syndrome (PCOS)-like symptoms including hyperandrogenism and oligo- or amenorrhoea.
Knight, PG +19 more
core +2 more sources
Expression of the neural cell adhesion NCAM in endocrine cells of the ovary [PDF]
In the adult mammalian ovary morphogenesis and differentiation processes are under hormonal control and, thus, occur in a highly regulated way during the sexual cycle.
Lahr, G. +2 more
core +1 more source
Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells : Implications for luteolysis [PDF]
The human LH receptor (LHR) plays a key role in luteal function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin.
Dickinson, Rachel E +4 more
core +1 more source
TGF-β1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways. [PDF]
Connective tissue growth factor (CTGF), which is also called CCN2, is a secreted matricellular protein. CTGF regulates various important cellular functions by interacting with multiple molecules in the microenvironment.
Jung-Chien Cheng +4 more
doaj +1 more source
The mechanisms underlining pathogenesis of polycystic ovary syndrome (PCOS) remain largely unknown. Dysfunction of ovarian granulosa cells plays an important role.
Yan Deng +14 more
doaj +1 more source
First year growth in the lithodids Lithodes santolla and Paralomis granulosa reared at different temperatures [PDF]
The southern king crab, Lithodes santolla Molina, and stone crab, Paralomis granulosa Jacquinot, inhabit the cold-temperate waters of southernmost South America (southern Chile and Argentina), where stocks of both species are endangered by overfishing ...
Calcagno, J.A. +15 more
core +1 more source
Flow cytometric analysis of steroidogenic organelles in differentiating granulosa cells
Functional and structural changes accompany the differentiation of granulosa cells during follicular development. We used flow cytometry and fluorescent dyes to characterize two organelles important to the steroidogenic process.
Yoshida, T. M. +3 more
core +9 more sources
Granulosa cell tumor of the ovary
Ovarian granulosa cell tumors (GCTs) are uncommon neoplasms that arise from the sex-cord stromal cells of the ovary. GCTs are characterized by long natural history and their tendency to recur years after the initial diagnosis. They present with symptoms and signs due to estradiol secretion, including vaginal bleeding and precocious puberty ...
Pectasides, D. +2 more
openaire +3 more sources
Lipid, fatty acid and protein utilization during lecithotrophic larval development of Lithodes santolla (Molina) and Paralomis granulosa (Jacquinot) [PDF]
During the larval development of the subantarctic king crab, Lithodes santolla, and stone crab, Paralomis granulosa, we compared changes in the carbon, fatty acid and protein contents of larvae reared under constant conditions from hatching to ...
Kattner, G. +13 more
core +1 more source
Here, we applied a model of long-term exposure of human granulosa cells to low environmentally relevant levels of di(2-ethylhexyl) phthalate (DEHP). This approach provides more relevant data regarding the impact of DEHP on the function of human granulosa
Fa Nedeljkovic, Svetlana +13 more
core +1 more source

