Results 41 to 50 of about 36,983 (206)
The Journal of Reproduction and Development, 2020 Specific gene expression in granulosa cells is key for the function of ovary, but the molecular mechanism of transcriptional activation is not well studied.
Shota MAYAMA +4 more
doaj +1 more source
Regulatory Mechanisms Underlying the Expression of Prolactin Receptor in Chicken Granulosa Cells. [PDF]
PLoS ONE, 2017 Prolactin (PRL) has both pro- and anti-gonadal roles in the regulation of avian ovarian functions through its interaction with the receptor (PRLR).
Shenqiang Hu +2 more
doaj +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Journal of Ovarian Research, 2020 Background We elucidated the role of specific MicroRNAs (miRNAs) in the development of polycystic ovary syndrome (PCOS) and explained the changes in the proliferation of granulosa cells. Excised ovarian cortex specimens were collected for miRNA profiling
Zhengfang Xiong +6 more
doaj +1 more source
The effect of total flavonoids of Epimedium on granulosa cell development in laying hens
Poultry Science, 2020 To investigate the impact of total flavonoids of Epimedium (TFE) on the development of follicles of laying hens, 3 types of follicles including primary, prehierarchical, and preovulatory follicles were selected to obtain the follicular granulosa cells ...
Yu Guo +7 more
doaj +1 more source
Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. [PDF]
PLoS ONE, 2013 Folliculogenesis is tightly controlled by a series of hormones, growth factors and cytokines, many of which are secreted as proproteins and require processing by proteases before becoming functional.
Xiaokui Yang +8 more
doaj +1 more source
Journal of Integrative Agriculture, 2021 Follicle-stimulating hormone (FSH), an important hypothalamic-pituitary-gonadal axis (HPG) hormone, is secreted by the pituitary gland. This study confirms that FSH is expressed in chicken follicles at different stages, and positive FSHβ mRNA signals ...
Yu-lin BI +4 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
The adipokines progranulin and omentin – novel regulators of basic ovarian cell functions
Reproductive Biology and EndocrinologyThe present study aimed to examine the effects of progranulin and omentin on basic ovarian cell functions. For this purpose, we investigated the effects of the addition of progranulin and omentin (0, 0.1, 1, or 10 ng/ml) on the viability, proliferation ...
Alexander V Sirotkin +4 more
doaj +1 more source
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source