Results 11 to 20 of about 4,453,459 (256)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling. [PDF]

Adv Sci (Weinh)
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Hu Q, Geng A, Li Z, Guo F, Wang J, Chen X, Zhang M, Zeng YA, Li W.   +8 more
europepmc   +2 more sources

Interaction between growing oocytes and granulosa cells in vitro [PDF]

Reproductive Medicine and Biology, 2020
Background Oocyte growth is accompanied by follicular development in mammalian ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15), knowledge of the bidirectional ...
Md Hasanur Alam, Takashi Miyano
doaj   +2 more sources

Granulosa Cells: Central Regulators of Female Fertility

Endocrines
Background: Granulosa cells are somatic cells within the ovarian follicle. As the primary site of estradiol production, they are critical regulators of several aspects of female reproduction.
Luis Fernando Schütz, Isadora M. Batalha   +1 more
doaj   +2 more sources

Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine

Cells
The necroptosis of granulosa cells has been proven to be one of the important triggers of follicular atresia, which is an important cause of reduced reproductive capacity in cows.
Xiaorui Yang, Yue Chen, Xinzi Wang, Gaoqing Xu, Hongjie Wang, Xinqi Shu, He Ding, Xin Ma, Jing Guo, Jun Wang, Jing Zhao, Yi Fang, Hongyu Liu, Wenfa Lu   +13 more
doaj   +2 more sources

Expression, transport, and storage of fetuin-B in human granulosa cells [PDF]

Scientific Reports
Fetuin-B is crucial in fertilization through inhibiting ovastacin, an enzyme that hardens the zona pellucida. Primarily synthesized in the liver, fetuin-B is also found in the placenta, tongue, and follicular fluid produced by granulosa cells. This study
Bartosz Linek, Ann-Christin Meyer, Carmen Schoppe, Thorsten Enklaar, Dirk Prawitt, Walburgis Brenner, Konstantin Hofmann   +6 more
doaj   +2 more sources

Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress. [PDF]

PLoS ONE, 2017
Various environmental insults including diseases, heat and oxidative stress could lead to abnormal growth, functions and apoptosis in granulosa cells during ovarian follicle growth and oocyte maturation.
Mohammed Saeed-Zidane, Lea Linden, Dessie Salilew-Wondim, Eva Held, Christiane Neuhoff, Ernst Tholen, Michael Hoelker, Karl Schellander, Dawit Tesfaye   +8 more
doaj   +1 more source

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

eLife, 2023
An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells.
Merrick D Pierson Smela, Christian C Kramme, Patrick RJ Fortuna, Jessica L Adams, Rui Su, Edward Dong, Mutsumi Kobayashi, Garyk Brixi, Venkata Srikar Kavirayuni, Emma Tysinger, Richie E Kohman, Toshi Shioda, Pranam Chatterjee, George M Church   +13 more
doaj   +1 more source

Effect of Vitamin D3 on Mitochondrial Biogenesis in Granulosa Cells Derived from Polycystic Ovary Syndrome [PDF]

International Journal of Fertility and Sterility, 2020
Background Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by anovulation hyperandro- genism. Hyperandrogenism increases apoptosis, which will eventually disturb follicular growth in PCOS patients.
Zahra Safaei, Mohammad Hossein Nasr Esfahani, Azadeh Akbari Sene, Vahid Najafzadeh, Mansoureh Soleimani, Reza Shirazi, Shabnam Bakhshalizadeh   +6 more
doaj   +1 more source

Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]

, 1992
We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J., Sterzik, K., Gratzl, Manfred, Mayerhofer, Artur   +3 more
core   +1 more source

Effects of angiogenin on granulosa and theca cell function in cattle

Animal, 2017
Angiogenin is a member of the ribonuclease A superfamily of proteins that has been implicated in stimulating angiogenesis but whether angiogenin can directly affect ovarian granulosa or theca cell function is unknown.
J.L. Dentis, N.B. Schreiber, A.M. Burress, L.J. Spicer   +3 more
doaj   +1 more source