Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress. [PDF]
PLoS ONE, 2017 Various environmental insults including diseases, heat and oxidative stress could lead to abnormal growth, functions and apoptosis in granulosa cells during ovarian follicle growth and oocyte maturation.
Mohammed Saeed-Zidane +8 more
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BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing
Journal of Ovarian Research, 2023 Background Granulosa cell proliferation and differentiation are essential for follicle development. Breast cancer amplified sequence 2 (BCAS2) is necessary for spermatogenesis, oocyte development, and maintaining the genome integrity of early embryos in ...
Xiaohong Yao +11 more
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eLife, 2023 An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells.
Merrick D Pierson Smela +13 more
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Effect of Vitamin D3 on Mitochondrial Biogenesis in Granulosa Cells Derived from Polycystic Ovary Syndrome [PDF]
International Journal of Fertility and Sterility, 2020 Background Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by anovulation hyperandro- genism. Hyperandrogenism increases apoptosis, which will eventually disturb follicular growth in PCOS patients.
Zahra Safaei +6 more
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Effects of angiogenin on granulosa and theca cell function in cattle
Animal, 2017 Angiogenin is a member of the ribonuclease A superfamily of proteins that has been implicated in stimulating angiogenesis but whether angiogenin can directly affect ovarian granulosa or theca cell function is unknown.
J.L. Dentis +3 more
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Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy
Frontiers in Cell and Developmental Biology, 2022 Aquaporin-8 (AQP8), a member of the aquaporin family, is strongly expressed in follicular granulosa cells, which could affect the hormone secretion level in females.
Binbin Huang +9 more
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Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]
, 1992 We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J. +3 more
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Interaction between growing oocytes and granulosa cells in vitro
Reproductive Medicine and Biology, 2020 Background Oocyte growth is accompanied by follicular development in mammalian ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15), knowledge of the bidirectional ...
Md Hasanur Alam, Takashi Miyano
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Activity of 3β-hydroxysteroid dehydrogenase associated with progesterone production in bovine granulosa cells cultured under different concentrations of serum, insulin-like growth factor I, and gonadotropin [PDF]
, 2014 Three-β-hydroxysteroid dehydrogenase (3β-HSD) is the enzyme responsible for progesterone production. This study aimed to determine whether 3β-HSD activity can be shown to reflect progesterone production by granulosa cells cultured under different serum
Mihm Carmichael, Monika, Şimsek, Özkan
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ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular–luteal transition
Life Science Alliance, 2023 ERK1/2 negatively regulates estradiol synthesis while positively regulating progesterone production in ovarian granulosa cells via the ERK1/2-SOX9/FOXL2 axis. Estradiol and progesterone are the primary sex steroids produced by the ovary. Upon luteinizing
Vijay Simha Baddela +4 more
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