Results 121 to 130 of about 5,004,988 (242)

TSPO expression in the adult ovary is localized to the interstitial cells and granulosa cells.

, 2013
Immunohistochemical localization of TSPO in ovaries from an adult 8-week-old mouse. (A) The staining pattern for TSPO in a section dissecting the entire ovary. There was strong expression of TSPO observed in the interstitial cells.
Newton S. Phuong (454429), Kanako Morohaku (454428), Vimal Selvaraj (446921)   +2 more
core   +1 more source

Long Non‐Coding RNAs: Key Regulators of Economic Traits in Livestock From Mechanisms to Breeding Applications

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Long non‐coding RNAs (lncRNAs) act as key regulators of economically important traits in livestock through diverse mechanisms including ceRNA networks, epigenetic regulation (X‐inactivation and imprinting) and liquid–liquid phase separation (LLPS).
Keyvan Khani, Mohammad Taher Harkinezhad, Rahimeh Sepehri   +2 more
wiley   +1 more source

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF‐κB/SOD2 Signaling Pathway

Advanced Science
Diminished ovarian reserve (DOR) is a physiological or pathological condition that progresses in an age‐dependent manner, which is characterized by impaired ovarian follicle quality, decreased anti‐Müllerian hormone levels, elevated follicle‐stimulating ...
Huiying Li, Siying Cai, Hongbei Mu, Tianli Chang, Xiaofei Wang, Tianyu Tang, Tengyun Dong, Yu Zhang, Ling Zhang, Huaibiao Li, Liquan Zhou, Wenpei Xiang   +11 more
doaj   +1 more source

Pyroptotic Macrophage Extracellular Vesicles Drive miR‐103a‐3p Mediated Mitochondrial Dysfunction in Granulosa Cells in Diminished Ovarian Reserve

Aging Cell, Volume 25, Issue 11, November 2026.
Pyroptotic macrophages release extracellular vesicles enriched in miR‐103a‐3p. These EVs are taken up by granulosa cells, where miR‐103a‐3p targets MFN2 and BCL2L13, disrupting mitochondrial homeostasis and increasing oxidative stress and apoptosis. This EV‐mediated signaling axis contributes to diminished ovarian reserve and represents a potential ...
Wenhan Ju, Xin Xin, Yanli Xiao, Liwen Song, Jinfu Zhang, Shan Xiang   +5 more
wiley   +1 more source

Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19)

, 2012
Inhibition of aromatase, the key enzyme in estrogen biosynthesis, is an important strategy in the treatment of breast cancer. Several dietary flavonoids show aromatase inhibitory activity, but their tissue specificity and mechanism remain unclear.
Wang, Fei, Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China, Zhang, Guo-lin, Lu, Dan-feng, Yang, Li-juan   +4 more
core  

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Silencing of METTL16 protects granulosa cells from the cisplatin-induced ferroptosis in premature ovarian failure

Cell Death Discovery
Premature ovarian failure (POF) and insufficiency induced by cisplatin are common complications associated with gynecological diseases. This study aims to investigate the role of N6-methyladenosine (m6A) methyltransferase METTL16 in cisplatin-induced ...
Jing Xiong, Ling He, Yongjing Zhang, Lifang Li   +3 more
doaj   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice

Journal of Nanobiotechnology
Background Nanoplastics (NPs) are emerging pollutants that pose risks to living organisms. Recent findings have unveiled the reproductive harm caused by polystyrene nanoparticles (PS-NPs) in female animals, yet the intricate mechanism remains ...
Yue Xue, Xiu Cheng, Zhang-Qiang Ma, Hou-Peng Wang, Chong Zhou, Jia Li, Da-Lei Zhang, Liao-Liao Hu, Yan-Fan Cui, Jian Huang, Tao Luo, Li-Ping Zheng   +11 more
doaj   +1 more source

NR4A1‐Driven Granulosa Cell Ferroptosis Contributes to Obesity‐Related Ovarian Dysfunction and Metformin‐Mediated Ovarian Protection

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Schematic illustrating that NR4A1‐driven granulosa cell ferroptosis mediates obesity‐related ovarian dysfunction, while metformin‐mediated ovarian protection is achieved via suppression of the PI3K/AKT–NR4A1 ferroptotic signaling cascade. ABSTRACT Obesity triggers ovarian dysfunction and female infertility accompanied by granulosa cell damage ...
Huihui Wang, Chaoying Wang, Shuaishuai Guo, Guang Yang, Junnan Fang, Jingyi Hu, Ran Jiang, Jun Zhai, Haixia Jin, Wenyan Song, Senlin Shi, Xianju Huang, Lin Qi, Zhaoting Wu, Yan Liu, Ning Song, Xiangyang Zhang, Guidong Yao   +17 more
wiley   +1 more source