Results 1 to 10 of about 664,422 (269)

Oligogenic basis of premature ovarian insufficiency: an observational study

Journal of Ovarian Research
Background The etiology of premature ovarian insufficiency, that is, the loss of ovarian activity before 40 years of age, is complex. Studies suggest that genetic factors are involved in 20–25% of cases.
Panpan Long, Le Wang, Hangjing Tan, Ruping Quan, Zihao Hu, Minghua Zeng, Ziheng Deng, Hualin Huang, Jonathan Greenbaum, Hongwen Deng, Hongmei Xiao   +10 more
doaj   +2 more sources

The risk factors, pathogenesis and treatment of premature ovarian insufficiency. [PDF]

J Ovarian Res
Premature ovarian insufficiency (POI) is a prevalent condition that impacts female reproductive health and overall well-being. It is characterized by ovarian dysfunction, estrogen deficiency, and increased gonadotropin levels in women under 40 years old.
Huang Y, Liu Z, Geng Y, Li F, Hu R, Song Y, Zhang M, Song K.   +7 more
europepmc   +2 more sources

BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

Nature Communications, 2022
Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction that results in infertility. Here they show that BCN1 mutation results in premature ovarian follicle activation and atresia through dysregulation of ferroptosis.
Feixia Wang, Yifeng Liu, Feida Ni, Jiani Jin, Yiqing Wu, Yun Huang, Xiaohang Ye, Xilin Shen, Yue Ying, Jianhua Chen, Ruixue Chen, Yanye Zhang, Xiao Sun, Siwen Wang, Xiao Xu, Chuan Chen, Jiansheng Guo, Dan Zhang   +17 more
doaj   +2 more sources

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS

EMBO Molecular Medicine, 2023
Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle‐stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown.
Xiao Guo, Yuemeng Zhu, Lu Guo, Yiwen Qi, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang, Chao Gu, Bin Li, Jin Li   +22 more
doaj   +2 more sources

Bone marrow mesenchymal stem cells expressing Neat-1, Hotair-1, miR-21, miR-644, and miR-144 subsided cyclophosphamide-induced ovarian insufficiency by remodeling the IGF-1–kisspeptin system, ovarian apoptosis, and angiogenesis

Journal of Ovarian Research
Ovarian insufficiency is one of the common reproductive disorders affecting women with limited therapeutic aids. Mesenchymal stem cells have been investigated in such disorders before yet, the exact mechanism of MSCs in ovarian regeneration regarding ...
Amany I. Ahmed, Mohamed F. Dowidar, Asmaa F. Negm, Hussein Abdellatif, Asma Alanazi, Mohammed Alassiri, Walaa Samy, Dina Mohamed Mekawy, Eman M. A. Abdelghany, Nesma I. El-Naseery, Mohamed A. Ibrahem, Emad Ali Albadawi, Wed Salah, Mamdouh Eldesoqui, Emil Tîrziu, Iulia Maria Bucur, Ahmed Hamed Arisha, Tarek Khamis   +17 more
doaj   +2 more sources

Loss of Calponin 2 causes premature ovarian insufficiency in mice

Journal of Ovarian Research
Background Premature ovarian insufficiency (POI) is a condition defined as women developing menopause before 40 years old. These patients display low ovarian reserve at young age and difficulties to conceive even with assisted reproductive technology ...
Tzu-Bou Hsieh, Jian-Ping Jin
doaj   +2 more sources

Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency

Frontiers in Cell and Developmental Biology, 2023
Primary ovarian insufficiency (POI) is an essential cause of young female fertility loss. At present, there are many treatments for primary ovarian insufficiency, but due to the complexity of the pathogenesis of primary ovarian insufficiency, the ...
Zixiang Geng, Zixiang Geng, Hailing Guo, Hailing Guo, Yifei Li, Ying Liu, Yongfang Zhao, Yongfang Zhao   +7 more
doaj   +1 more source

Premature ovarian insufficiency

Best Practice & Research Clinical Obstetrics & Gynaecology, 2022
The natural lifespan of the ovary is occasionally interrupted by pathological processes; some are known, but many are unknown. Premature ovarian insufficiency (POI) can be a devastating diagnosis for an adolescent or for someone who has yet to start a family.
Sinéad M. McGlacken-Byrne, Gerard S. Conway   +1 more
openaire   +2 more sources

Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency. [PDF]

PLoS ONE, 2014
The primary objectives of the present study are to determine the period of onset of ovarian insufficiency after surgery and to confirm potential risk factors for ovarian insufficiency after surgery for the removal of benign ovarian cysts.
Seido Takae, Kazuhiro Kawamura, Yorino Sato, Chie Nishijima, Nobuhito Yoshioka, Yodo Sugishita, Yuki Horage, Mamoru Tanaka, Bunpei Ishizuka, Nao Suzuki   +9 more
doaj   +1 more source

Prevalence of cytogenetic abnormalities and FMR1 gene premutation in a Portuguese population with premature ovarian insufficiency

Acta Médica Portuguesa, 2021
Introduction: Chromosome abnormalities contribute to about 10% of cases of premature ovarian insufficiency. Most are associated with X chromosome. Fragile mental retardation 1 (FMR1) gene premutation has an estimated prevalence of 1% - 7% in sporadic ...
Ana Raquel Neves, Ana Sofia Pais, Susana Isabel Ferreira, Vera Ramos, Maria João Carvalho, Alexandra Estevinho, Eunice Matoso, Fernanda Geraldes, Isabel Marques Carreira, Fernanda Águas   +9 more
doaj   +1 more source