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Primary ovarian insufficiency. [PDF]

CMAJ, 2023
Brent S, Christakis M, Shirreff L.
europepmc   +10 more sources

The role of anti-Müllerian hormone: insights into ovarian reserve, primary ovarian insufficiency, and menopause prediction. [PDF]

Endocrine
This review highlights the role of Anti-Müllerian Hormone (AMH) in ovarian insufficiency and as a predictor of menopause. AMH, produced by granulosa cells in growing follicles, is a key marker of ovarian reserve, reflecting the remaining pool of viable ...
Karaviti E, Karaviti D, Kani ER, Chatziandreou E, Paschou SA, Psaltopoulou T, Kalantaridou S, Lambrinoudaki I.   +7 more
europepmc   +2 more sources

Primary ovarian insufficiency: update on clinical and genetic findings. [PDF]

Front Endocrinol (Lausanne)
Primary ovarian insufficiency (POI) is a disorder of insufficient ovarian follicle function before the age of 40 years with an estimated prevalence of 3.7% worldwide.
Federici S, Rossetti R, Moleri S, Munari EV, Frixou M, Bonomi M, Persani L.   +6 more
europepmc   +2 more sources

Autoimmune Disease is Increased in Women With Primary Ovarian Insufficiency.

J Clin Endocrinol Metab
Context Autoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.
Wang V, Walsh JA, Zell J, Verrilli LE, Letourneau JM, Johnstone EB, Allen-Brady K, Welt CK.   +7 more
europepmc   +2 more sources

Searching for the 'X' factor: investigating the genetics of primary ovarian insufficiency. [PDF]

J Ovarian Res
Primary ovarian insufficiency (POI) is the cessation of ovarian function before the age of 40. The causes of POI are heterogeneous, but substantial evidence exists to support a genetic basis of POI, particularly in the critical involvement of genes on ...
Knight A, Sugin S, Jurisicova A.
europepmc   +2 more sources

Identification of genetically engineered strategies to manipulate nano-platforms presenting immunotherapeutic ligands for alleviating primary ovarian insufficiency progression. [PDF]

Cell Commun Signal
Primary ovarian insufficiency (POI) is a pathological condition characterized by the early loss of functional ovarian follicles, leading to infertility and systemic consequences affecting reproductive, skeletal, cardiovascular, and neurocognitive helath.
Zhou G, Gu Y, Zhang M, Ding J, Lu G, Hua K, Shen F.   +6 more
europepmc   +2 more sources

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency. [PDF]

Int J Mol Sci, 2023
Young female cancer patients can develop chemotherapy-induced primary ovarian insufficiency (POI). Cyclophosphamide (Cy) is one of the most widely used chemotherapies and has the highest risk of damaging the ovaries. Recent studies elucidated the pivotal
Xu Z, Takahashi N, Harada M, Kunitomi C, Kusamoto A, Koike H, Tanaka T, Sakaguchi N, Urata Y, Wada-Hiraike O, Hirota Y, Osuga Y.   +11 more
europepmc   +2 more sources

Breast Cancer Is Increased in Women With Primary Ovarian Insufficiency.

J Clin Endocrinol Metab
Context DNA damage/repair gene variants are associated with both primary ovarian insufficiency (POI) and cancer risk. Objective We hypothesized that a subset of women with POI and family members would have increased risk for cancer.
Allen-Brady K, Moore B, Verrilli LE, Alvord MA, Kern M, Camp N, Kelley K, Letourneau J, Cannon-Albright L, Yandell M, Johnstone EB, Welt CK.   +11 more
europepmc   +2 more sources

Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency. [PDF]

Nat Genet
Age at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS) under an additive model, other genetic models are ...
Oddsson A, Steinthorsdottir V, Oskarsson GR, Styrkarsdottir U, Moore KHS, Isberg S, Halldorsson GH, Sveinbjornsson G, Westergaard D, Nielsen HS, Fridriksdottir R, Jensson BO, Arnadottir GA, Jonsson H, Sturluson A, Snaebjarnarson AS, Andreassen OA, Walters GB, Nyegaard M, Erikstrup C, Steingrimsdottir T, Lie RT, Melsted P, Jonsdottir I, Halldorsson BV, Thorleifsson G, Saemundsdottir J, Magnusson OT, DBDS Genomic Consortium, Banasik K, Sorensen E, Masson G, Pedersen OB, Tryggvadottir L, Haavik J, Ostrowski SR, Stefansson H, Holm H, Rafnar T, Gudbjartsson DF, Sulem P, Stefansson K.   +41 more
europepmc   +2 more sources

Primary Ovarian Insufficiency, Bone Health, and Other Outcomes in Adolescents. [PDF]

Obstet Gynecol Clin North Am
Adolescents with primary ovarian insufficiency (POI) frequently present with arrested pubertal development or amenorrhea. Early evaluation of menstrual irregularities can avoid a delayed diagnosis.
Cipres DT, Gordon CM.
europepmc   +2 more sources