Results 41 to 50 of about 114,971 (282)

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Mitochondrial Dysfunction in Primary Ovarian Insufficiency [PDF]

Endocrinology, 2019
Abstract Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep disturbances, and depression, as well as reduced fertility and increased long-term risk of cardiovascular disease.
Dov Tiosano, Jason A Mears, David A Buchner   +2 more
openaire   +2 more sources

Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles

Reproductive Medicine and Biology, 2023
Primary ovarian insufficiency (POI) is characterized by the development of hypergonadotropic hypogonadism before 40 years of age and leads to intractable infertility. Although in vitro fertilization and embryo transfer with donated eggs enables pregnancy,
S. Osuka, Yukiyo Kasahara, S. Iyoshi, R. Sonehara, Natsuki Myake, A. Muraoka, Tomoko Nakamura, Akira Iwase, Hiroaki Kajiyama   +8 more
semanticscholar   +1 more source

New directions for the treatment of adrenal insufficiency [PDF]

, 2015
The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Allen, Allende, Badylak, Bancos, Berkes, Birke, Buaas, Chamoux, Chamoux, Clipsham, Cogger, Cox, Crawford, Drucker, Dubernard, El-Khairi, Else, Faulk, Fayard, Franksson, Freedman, Gallo-Payet, Gondo, Gondo, Grodstein, Guasti, Guasti, Hardy, Hardy, Hardy, Hardy, Hatano, Huang, Huang, Ibbertson, Jadhav, Kearns, Kim, King, Laufer, Ludwig, Luo, Mazilu, Parker, Sancho-Martinez, Schimmer, Schnabel, Sonoyama, Takahashi, Tanaka, Teebken, Thomas, Thomas, Thomas, Thomas, Thomas, Val, Val, Vierbuchen, Vouillarmet, Walczak, Walczak, Wei, Wilhelm, Wong, Yazawa, Yazawa, Yazawa, Yazawa, Zupekan   +69 more
core   +2 more sources

Primary Ovarian Insufficiency [PDF]

New England Journal of Medicine, 2009
A 30-year-old woman presents with a history of no menses since she stopped taking oral contraceptives 6 months ago in order to conceive. She had undergone puberty that was normal in both timing and development, with menarche at 12 years of age. At 18 years of age, she started taking oral contraceptives for irregular menses.
openaire   +1 more source

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]

, 2011
The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew, Heytens, Elke, Oktay, Kutluk, Soleimani, Reza   +3 more
core   +1 more source

Endocrinology of Primary Ovarian Insufficiency: Diagnostic and Therapeutic Clues

Endocrines
Background: This paper briefly reviews the most important endocrine features of primary ovarian insufficiency (POI) and shows their relevance for the diagnosis and treatment of this condition.
Jan Tesarik
semanticscholar   +1 more source

The Genetics of Non-Syndromic Primary Ovarian Insufficiency: A Systematic Review [PDF]

, 2019
Several causes for primary ovarian insufficiency (POI) have been described, including iatrogenic and environmental factor, viral infections, chronic disease as well as genetic alterations.
Arduino, Bruno, CARLEA, ANNUNZIATA, D'Alessandro, Pietro, De Marco, Carmela, De Vivo, Valentino, Improda, Francesco Paolo, Lico, Daniela, Rania, Erika, Saccone, Gabriele, Venturella, Roberta, Viglietto, Giuseppe, Zullo, Fulvio   +11 more
core   +1 more source

Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency

Journal of Biomedical Sciences
Primary ovarian insufficiency (POI) is an early decline in ovarian function that leads to ovarian failure. Conventional treatments for POI are inadequate, and treatments based on mesenchymal stem cells (MSCs) have emerged as an option.
Duy-Cuong Le, M. T. Ngo, Yung-Che Kuo, Shu-Hwa Chen, Chung-Yen Lin, T. Ling, Q. T. T. Pham, Heng-Kien Au, Jihwan Myung, Yen-Hua Huang   +9 more
semanticscholar   +1 more source

Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells

Autophagy, 2022
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown.
Wenwen Liu, Min Chen, Chao Liu, Liying Wang, Huafang Wei, Ruidan Zhang, Zhengxing Ren, Yinghong Chen, Mengcheng Luo, Jianguo Zhao, Hongwei Jiang, F. Gao, Wei Li   +12 more
semanticscholar   +1 more source