Results 11 to 20 of about 114,971 (282)

Identifying therapeutic targets for primary ovarian insufficiency through integrated genomic analyses. [PDF]

J Ovarian Res
Primary ovarian insufficiency (POI) is a disorder characterized by the premature decline in ovarian function, leading to significant fertility and health impacts on women under 40.
Du H, Zeng P, Liu X, Zhang J, Huang Z.
europepmc   +2 more sources

Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection. [PDF]

Stem Cell Res Ther
Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast cancer and cardiovascular disease.
Dai F, Liu H, He J, Wu J, Yuan C, Wang R, Yuan M, Yang D, Deng Z, Wang L, Wang Y, Yang X, Wang H, Hu W, Cheng Y.   +14 more
europepmc   +2 more sources

Association of Polymorphisms in FSHR, ESR1, and BMP15 with Primary Ovarian Insufficiency and Meta-Analysis. [PDF]

Diagnostics (Basel)
Primary ovarian insufficiency (POI) can lead to menstrual disturbance, resulting in ovarian dysfunction before age 40. Prevalence of POI is usually less than 1%; however, ethnicity or population characteristics may affect prevalence.
Lee JY, Kim YR, Ko EJ, Ryu CS, Kwack K, Na ED, Shin JE, Kim JH, Ahn EH, Kim NK.   +9 more
europepmc   +2 more sources

Family size for women with primary ovarian insufficiency and their relatives. [PDF]

Hum Reprod, 2023
STUDY QUESTION How does the number of children in women with primary ovarian insufficiency (POI) compare to the number for control women across their reproductive lifespans?
Verrilli LE, Allen-Brady K, Johnstone EB, Alvord MA, Welt CK.   +4 more
europepmc   +2 more sources

Mesenchymal stem cell-derived extracellular vesicles therapy for primary ovarian insufficiency: a systematic review and meta-analysis of pre-clinical studies. [PDF]

J Ovarian Res
Primary ovarian insufficiency (POI) manifests with hormonal imbalances, menstrual irregularities, follicle loss, and infertility. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are emerging as a promising treatment for POI.
Firouzabadi SR, Mohammadi I, Ghafourian K, Mofidi SA, Firouzabadi SR, Hashemi SM, Tehrani FR, Jafarabady K.   +7 more
europepmc   +2 more sources

Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency [PDF]

, 2013
PURPOSE: Primary ovarian insufficiency before the age of 40 years affects 1% of the female population and is characterized by permanent cessation of menstruation. Genetic causes include FMR1 expansion mutations.
A Marozzi, A Murray, A Murray, AJ Swerdlow, Alan Ashworth, Anna Murray, Anthony J. Swerdlow, B Bodega, BA Oostra, BJ Cairns, CB Coulam, CB Karimov, CE Bennett, Claire E. Bennett, Danielle H. Morris, DH Morris, DJ Allingham-Hawkins, EG Allen, GS Conway, James N. Macpherson, JR Brouwer, K Gersak, KL Bretherick, L Persani, LM Nelson, Michael Jones, Minouk J. Schoemaker, Nick Orr, Patricia A. Jacobs, R Willemsen, S Ennis, Sarah Ennis, SD Sullivan, SL Nolin   +33 more
core   +2 more sources

Mutations in NR5A1 Associated with Ovarian Insufficiency [PDF]

, 2009
BackgroundThe genetic causes of nonsyndromic ovarian insufficiency are largely unknown. A nuclear receptor, NR5A1 (also called steroidogenic factor 1), is a key transcriptional regulator of genes involved in the hypothalamic-pituitary-steroidogenic axis.
Achermann, John C., Bashamboo, Anu, Boudjenah, Radia, Brauner, Raja, De Perdigo, Arantzazu, Guerra-Junior, Gil, Lin, Lin, Lourenco, Diana, Maciel-Guerra, Andrea T., McElreavey, Ken, Muresan, Mihaela, Weryha, Georges   +11 more
core   +1 more source

BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

Nature Communications, 2022
Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by premature exhaustion of primordial follicles. POI causes infertility, severe daily life disturbances and long-term health risks.
Feixia Wang, Yifeng Liu, Feida Ni, Jiani Jin, Yi-qing Wu, Yun Huang, Xiaohang Ye, X. Shen, Y. Ying, Jianhua Chen, Ruixue Chen, Yanye Zhang, Xiao Sun, Siwen Wang, Xiao Xu, Chuan Chen, Jiansheng Guo, Dan Zhang   +17 more
semanticscholar   +1 more source

Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]

, 2018
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
core   +1 more source

Comparison of the therapeutic effects between stem cells and exosomes in primary ovarian insufficiency: as promising as cells but different persistency and dosage

Stem cell research & therapeutics, 2023
Background Primary ovarian insufficiency (POI) refers to the loss of ovarian function under the age of 40 and results in amenorrhea and infertility. Our previous studies have shown that transplantation of mesenchymal stem cells (MSCs) and MSC-derived ...
Hang-soo Park, R. Chugh, J. Seok, E. Cetin, H. Mohammed, Hiba Siblini, Farzana Begum Liakath Ali, M. M. Ghasroldasht, Hiba Alkelani, A. Elsharoud, Mara Ulin, Sahar Esfandyari, A. Al-Hendy   +12 more
semanticscholar   +1 more source