Results 31 to 40 of about 664,422 (269)

Selected Genetic Factors Associated with Primary Ovarian Insufficiency

International Journal of Molecular Sciences, 2023
Primary ovarian insufficiency (POI) is a heterogeneous disease resulting from non-functional ovaries in women before the age of 40. It is characterized by primary amenorrhea or secondary amenorrhea.
Mengchi Chen, Haotian Jiang, Chunping Zhang   +2 more
semanticscholar   +1 more source

Reporting on the Role of miRNAs and Affected Pathways on the Molecular Backbone of Ovarian Insufficiency: A Systematic Review and Critical Analysis Mapping of Future Research

Frontiers in Cell and Developmental Biology, 2021
Ovarian insufficiency is identified as a perplexing entity in the long list of pathologies impairing fertility dynamics. The three distinct classifications of ovarian insufficiency are poor ovarian response, premature ovarian insufficiency/failure, and ...
Anna Rapani, Anna Rapani, Dimitra Nikiforaki, Dimitra Karagkouni, Dimitra Karagkouni, Konstantinos Sfakianoudis, Petroula Tsioulou, Petroula Tsioulou, Sokratis Grigoriadis, Sokratis Grigoriadis, Evangelos Maziotis, Evangelos Maziotis, Amelia Pantou, Aikaterini Voutsina, Agni Pantou, Michael Koutsilieris, Artemis Hatzigeorgiou, Artemis Hatzigeorgiou, Konstantinos Pantos, Mara Simopoulou, Mara Simopoulou   +20 more
doaj   +1 more source

Human UC-MSC-derived exosomes facilitate ovarian renovation in rats with chemotherapy-induced premature ovarian insufficiency

Frontiers in Endocrinology, 2023
Premature ovarian insufficiency (POI) induced by chemotherapy is an intractable disorder with a considerable incidence that commonly results in insufficient fertility and concomitant complications in female patients.
Xiaodi Pu, Leisheng Zhang, Peiyu Zhang, Yaqiong Xu, Jun Wang, Xiaomei Zhao, Zhihua Dai, Hua Zhou, Shuyun Zhao, Anran Fan   +9 more
semanticscholar   +1 more source

How polymorphic markers contribute to genetic diseases in different populations? The study of inhibin A for premature ovarian insufficiency

Einstein (São Paulo)
Objective To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls.
Denise Maria Christofolini, Emerson Barchi Cordts, Fernando Santos-Pinheiro, Erika Azuma Kayaki, Mayla Cristina Fernandes Dornas, Monise de Castro Santos, Bianca Bianco, Caio Parente Barbosa   +7 more
doaj   +1 more source

Primary ovarian insufficiency: update on clinical and genetic findings

Frontiers in Endocrinology
Primary ovarian insufficiency (POI) is a disorder of insufficient ovarian follicle function before the age of 40 years with an estimated prevalence of 3.7% worldwide.
S. Federici, R. Rossetti, S. Moleri, E. Munari, Maria Frixou, M. Bonomi, L. Persani   +6 more
semanticscholar   +1 more source

Comparison of the therapeutic effects between stem cells and exosomes in primary ovarian insufficiency: as promising as cells but different persistency and dosage

Stem cell research & therapeutics, 2023
Background Primary ovarian insufficiency (POI) refers to the loss of ovarian function under the age of 40 and results in amenorrhea and infertility. Our previous studies have shown that transplantation of mesenchymal stem cells (MSCs) and MSC-derived ...
Hang-soo Park, R. Chugh, J. Seok, E. Cetin, H. Mohammed, Hiba Siblini, Farzana Begum Liakath Ali, M. M. Ghasroldasht, Hiba Alkelani, A. Elsharoud, Mara Ulin, Sahar Esfandyari, A. Al-Hendy   +12 more
semanticscholar   +1 more source

Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression

Reproductive Biology and Endocrinology, 2022
Background The protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway regulates early follicular activation and follicular pool maintenance in female germline cells.
Julia Rehnitz, Birgitta Messmer, Ulrike Bender, Xuan Phuoc Nguyen, Ariane Germeyer, Katrin Hinderhofer, Thomas Strowitzki, Edison Capp   +7 more
doaj   +1 more source

The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency

Antioxidants, 2023
Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in young women.
A. Shelling, Noha Ahmed Nasef
semanticscholar   +1 more source

Expression profiles of miR-23a and miR-146a in the peripheral blood of women with premature ovarian insufficiency

Einstein (São Paulo)
Objective This study aimed to analyze the expression profiles of miR-23a and miR-146a in women with premature ovarian insufficiency and to evaluate their value as biomarkers of the disease for early diagnosis and prognosis, as well as effective ...
Thérèse Rachell Theodoro, Rafael Bitelman Barreiro, Isabella Verdi Cunha, Bianca Bianco, Caio Parente Barbosa, Denise Maria Christofolini   +5 more
doaj   +1 more source

Menarche in primary ovarian insufficiency after a month of hormone replacement therapy: a case report

Journal of Medical Case Reports, 2021
Background Gynecologic anomalies, including uterine agenesis and ovarian dysgenesis, are some of the several differential diagnoses in adolescent females with primary amenorrhea and delayed puberty.
Biwen Cheng
doaj   +1 more source