Results 81 to 90 of about 664,422 (269)

Successful Pregnancy after Treatment with Chinese  Herbal Medicine in a 43‐Year‐Old Woman with  Diminished Ovarian Reserve and Multiple Uterus  Fibrosis: A Case Report

Medicines, 2017
Objective: To highlight a natural approach to coexisting oligomenorrhea, subfertility,  luteal phase insufficiency and multiple fibroids cohesively when in vitro fertilisation (IVF) has  failed.
Benqi Teng, Jie Peng, Madeleine Ong, Xianqin Qu   +3 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Genetic etiology of primary premature ovarian insufficiency

Acta Clinica Croatica, 2016
Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40 ...
Maja Franić-Ivanišević, Damir Franić, Miomira Ivović, Milina Tančić-Gajić, Ljiljana Marina, Marija Barac, Svetlana Vujović   +6 more
doaj   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

RMND1 and PLN variants are the underlying cause of Perrault‐like syndrome and cardiac anomalies in a patient

Clinical Case Reports
Key Clinical Message Recent studies have established an association between RMND1 variants and Perrault syndrome. In this case report, we present a female patient with Perrault syndrome and cardiomyopathy, resulting from variants in RMND1 and PLN ...
Xiaoli Du, Cara L. Barnett, Kimberly M. Widmeyer, Xinjian Wang, Diana S. Brightman, Carolee W. Noonan, Kathryn N. Weaver, Robert J. Hopkin, Yaning Wu   +8 more
doaj   +1 more source

Psychological stressors involved in the pathogenesis of premature ovarian insufficiency and potential intervention measures

Gynecological Endocrinology
Premature ovarian insufficiency (POI) is a common gynecological endocrine disease, which seriously affects women’s physical and mental health and fertility, and its incidence is increasing year by year.
Ying Xu, Jiating Fu, Zhilin Hong, Defei Zeng, Chao Guo, Ping Li, Jin-xiang Wu   +6 more
semanticscholar   +1 more source

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

Research progress on the effect of chemotherapy drugs on ovarian function in breast cancer

Zhongguo linchuang yanjiu
In women with reproductive potential, ovarian dysfunction caused by chemotherapy for breast cancer has far-reaching effects. Ovarian insufficiency can manifest as amenorrhea, menstrual disorders, hot flashes and night sweats, impaired fertility in the ...
HUANG Miaojun, TENG Yueyue, HUANG Shengchao, LI Jianwen, ZHANG Yuanqi   +4 more
doaj   +1 more source