Results 91 to 100 of about 581,151 (252)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Histological Pattern Of Ovarian Neoplasms And Their Age Wise Distribution-Study Conducted At A Tertiary Care Hospital

Journal of Rawalpindi Medical College, 2019
Background: Ovarian cancer is the 6th most common cancer in females in USA. The purpose of this study is to determine the distribution of histopathological types of ovarian cancers in different age groups of females to provide an institutional experience.
Fazeelat Iftikhar, Hira Anum, Naghmana Iftikhar, Ammara Ijaz, Naima Gul   +4 more
doaj  

Multicentric peripheral T-cell lymphoma, bilateral granulosa cell tumor, and papillary ovarian adenocarcinoma in a female dog - case report

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The frequency of ovarian neoplasms in dogs is low, and these tumors are often underdiagnosed mainly due to nonspecific clinical signs. Multiple ovarian tumors are rarely described in dogs and can be of primary or secondary origin. Lymphomas, in turn, are
J.G. Wronski, K.Y.R. Nakagaki, E.A. Viscone, M.M. Nunes, G.D. Cassali   +4 more
doaj   +1 more source

Second neoplasms after invasive and borderline ovarian cancer

, 2009
Excess risk of subsequent cancers has been documented in women diagnosed with ovarian cancer. We updated to 2006 data on second cancers in women diagnosed with invasive and borderline ovarian cancer in the Swiss canton of Vaud. Between 1974 and 2006, 304
C. La Vecchia, L. Randimbison, R. Blanc Moya, F. Levi, Randimbison, Lalao, La Vecchia, Carlo, La Vecchia C, Levi F, Levi, Fabio, Blanc-Moya R, Randimbison L, Blanc-Moya, Rafael, Rafael Blanc-Moya, Carlo La Vecchia, Fabio Levi, Lalao Randimbison   +15 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

COMPARATIVE CHARACTERISTICS OF THE AVAILABLE LABORATORY TESTS AND THEIR COMBINATIONS USED IN DIFFERENTIAL DIAGNOSIS OF OVARIAN NEOPLASMS

Акушерство, гинекология и репродукция, 2018
n the case of a space-occupying lesion (SOL) of the ovary, it is up to the gynecologist to diagnose a possible malignancy and then decide upon further treatment strategy.
M. A. Egunova, I. G. Kutsenko
doaj   +1 more source

Ovarian Neuroendocrine Neoplasms: Challenges and Future Perspectives

Background: Ovarian neuroendocrine neoplasms (O-NENs) are extremely rare, representing less than 1% of all ovarian neoplasms and under 5% of all neuroendocrine tumors (NETs).
Veroi, Gabriele, Grillo, Lucia Rosalba, Maria Cristina Macciomei, Anna La Salvia, La Salvia, Anna, Carla Lubrano, Di Vito, Valentina, Rindi, Guido, Baiocchini, Andrea, Andrea Baiocchini, Rota, Francesca, Baldelli, Roberto, Lania, Andrea, Gabriele Veroi, Laura Rizza, Guido Rindi, Silvia Migliaccio, Francesca Rota, Macciomei, Maria Cristina, Roberto Baldelli, Lucia Rosalba Grillo, Lubrano, Carla, Migliaccio, Silvia, Valentina Di Vito, Rizza, Laura, Andrea Lania, Baldelli R., Lania A., Rota F., La Salvia A., Baiocchini A., Lubrano C., Rindi G., Migliaccio S., Macciomei M. C., Veroi G., Grillo L. R., Rizza L., Di Vito V.   +38 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Role of Alpha-Smooth Muscle Actin and Fibroblast Activation Protein Alpha in Ovarian Neoplasms

, 2018
<b><i>Background/Aims:</i></b> Studies show that tumor growth is not just determined by the presence of malignant cells, since interactions between cancer cells and stromal microenvironment have important impacts on the cancer ...
Renata Margarida Etchebehere, Ana Carolinne da Silva, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini, Millena Prata Jammal   +4 more
core   +1 more source

Clinico pathological study of ovarian neoplasms [PDF]

, 2017
Background: Ovarian tumors are common form of neoplasm in women and account for 30% of female genital tract cancers. Ovarian cancer is the sixth most common cancer in women and the leading cause of death in women with gynaecological malignancy.
Lina Baru, Ranjita Patnaik, Singh, Kunja Bihari, Kunja Bihari Singh, Baru, Lina, Patnaik, Ranjita   +5 more
core   +1 more source