Results 241 to 250 of about 36,284 (310)
Advanced Intelligent Systems, EarlyView.This article offers a comprehensive review of topic modeling techniques, tracing their evolution from inception to recent developments. It explores methods such as latent Dirichlet allocation, latent semantic analysis, non‐negative matrix factorization, probabilistic latent semantic analysis, Top2Vec, and BERTopic, highlighting their strengths ...
Pratima Kumari +6 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.Researchers develop clinlabomics assisted for cancer identification, an artificial intelligence‐powered system using routine clinical lab data to detect and identify 10 cancer types. Tested on 19 199 individuals, it achieves 90.39% sensitivity and 82.41% specificity in cancer detection, with 72.57% accuracy in identifying specific cancer types ...
Bowen Zhang +9 more
wiley +1 more source
The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast
Animal Models and Experimental Medicine, EarlyView.The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij +8 more
wiley +2 more sources
Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling
Annals of Neurology, EarlyView.Objective Hyperactive KCNT1 potassium channels, caused by gain‐of‐function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug‐resistant seizures and, in cases with infantile onset, developmental regression can follow.
Michael G. Ricos +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.Here, we introduce a design strategy for activated photosensitizers (PSs) wherein photoinduced electron transfer (PeT) is combined with a process of self‐assembly that can be regulated by endogenous H2S—a tumor‐associated biomarker to favor Type‐I photochemical reactions.
Huiyu Niu +12 more
wiley +2 more sources
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, EarlyView.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
Angewandte Chemie, EarlyView.A novel Os(II)‐Pt(IV)‐Ceritinib (Os‐Pt‐Cer) conjugate enables triple‐action anticancer therapy by integrating photodynamic therapy, chemotherapy, and immunogenic cell death (ICD) induction into a single molecule. Upon near‐infrared light activation, this heterobimetallic complex exhibits potent antiproliferative effects in ovarian cancer models ...
Marta Redrado +10 more
wiley +2 more sources