Results 31 to 40 of about 624,533 (255)

Vitamin D Does not Have Any Impact on Ovarian Reserve Markers in Infertile Women

Gynecology Obstetrics & Reproductive Medicine, 2017
Objective: To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns. Study design: This prospective cross-sectional study included the infertile women attending the Hitit University ...
Ümit Görkem, Ferit Kerim Küçükler, Cihan Toğrul, Şebnem Gülen   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Endometriosis, Ovarian Reserve and Live Birth Rate Following In Vitro Fertilization/Intracytoplasmic Sperm Injection [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2016
Purpose To evaluate whether women with endometriosis have different ovarian reserves and reproductive outcomes when compared with women without this diagnosis undergoing in vitro fertilization/intracytoplasmic sperm injection ( IVF/ ICSI), and to ...
Marcela Alencar Coelho Neto, Wellington de Paula Martins, Caroline Mantovani da Luz, Bruna Talita Gazeto Melo Jianini, Rui Alberto Ferriani, Paula Andrea Navarro   +5 more
doaj   +1 more source

Evaluating the role of serum AMH in predicting suboptimal or excessive ovarian response to standard dosing regimen of ovarian stimulation in in-vitro fertilisation using GNRH agonist long protocol [PDF]

, 2011
Introduction: Antral follicle count (AFC) is widely used for individualising gonadotrophin dosage in in-vitro fertilisation (IVF) treatment. This retrospective study tried to determine whether baseline serum anti-Mullerian hormone (AMH) measurement ...
Li, RHW, Ho, PC, Lee, VCY, Lau, EYL, Ng, EHY, Yeung, WSB   +5 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PREDICTION OF DECREASE IN OVARIAN RESERVE IN ADOLESCENT GIRLS USING A COMPUTER PROGRAM

Мать и дитя в Кузбассе, 2020
Aim – development of a computer program for assessing ovarian reserve in adolescent girls and forecasting its decline. Object of research. The object of the study were 200 adolescent girls 15-16 years old born premature and full-term.
Светлана Ивановна Елгина, Елена Николаевна Никулина   +1 more
doaj  

Follicle Stimulating Hormone and Anti-Müllerian Hormone among Fertile and Infertile Women in Ile-Ife, Nigeria: Is there A Difference? [PDF]

International Journal of Fertility and Sterility, 2017
Background Reduced ovarian reserve predicts poor ovarian response and poor suc- cess rates in infertile women who undergo assisted reproductive technology (ART).
Temitope Okunola, Kayode Olusegun Ajenifuja, Olabisi Morebise Loto, Afolabi Salawu, Stephen Oluseyi Omitinde   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Evaluation of Ovarian Reserve in Women With Rheumatoid Arthritis

Journal of Family and Reproductive Health, 2021
Objective: Subfertility is commonly observed in patients with rheumatoid arthritis (RA). Although the causes are not well established, the alteration of the ovarian reserve is thought to contribute to the lower chances of pregnancy.
Sara Patricia Peña-Lizola, Luis Humberto Sordia-Hernandez, Selene Marysol Garcia-Luna, Otto Valdes-Martinez, Cassandra Michele Skinner-Taylor, Mario Alberto Garza-Elizondo, OScar Vidal-Gutierrez, Jesus Zacarias Villarreal-Perez, Miryam Eguia-Bernal, Felipe Arturo Morales-Martinez   +9 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source