Results 81 to 90 of about 61,342 (328)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Assessment and prediction models for the quantitative and qualitative reserve of the ovary using machine learning

Journal of Ovarian Research
Background The age-related decline of fertility is caused by a reduction of the ovarian reserve, which is represented by the number and quality of oocytes in the ovaries.
Hiroshi Koike, Miyuki Harada, Kaname Yoshida, Katsuhiko Noda, Chihiro Tsuchida, Toshihiro Fujiwara, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi, Chisato Kunitomi, Nozomi Takahashi, Yoko Urata, Kenbun Sone, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga   +16 more
doaj   +1 more source

Psychological stress is related to a decrease of serum anti-müllerian hormone level in infertile women

Reproductive Biology and Endocrinology, 2017
Background Stress exposure has been proved to be linked to reproductive failure. The reproductive potential of women depends on the ovarian reserve. Anti-müllerian hormone (AMH) has been proved a reliable clinical marker of ovarian reserve.
Yue-zhi Dong, Fei-jing Zhou, Ying-pu Sun
doaj   +1 more source

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. [PDF]

, 2018
An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject.
Bedard, Jenna, Landis, Jessica, Marin, Diego, Morin, Scott J., Scott, Richard T., Seli, Emre, Tao, Xin, Zhan, Yiping   +7 more
core   +1 more source

Fertility preservation in ovarian tumours [PDF]

, 2018
A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5 ...
Bardhi, E., Di Donato, V., Di Pinto, A., Muzii, L., Panici, P. B., Peccatori, F. A., Petrella, M. C., Sassu, C. M., Tomao, F.   +8 more
core   +1 more source

Defining ovarian reserve to better understand ovarian aging [PDF]

Reproductive Biology and Endocrinology, 2011
Though a widely utilized term and clinical concept, ovarian reserve (OR) has been only inadequately defined. Based on Medline and PubMed searches we here define OR in its various components, review genetic control of OR, with special emphasis on the FMR1 gene, and discuss whether diminished OR (DOR) is treatable.
Gleicher Norbert, Weghofer Andrea, Barad David H   +2 more
openaire   +3 more sources

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve

International Journal of Endocrinology, 2013
Accumulating evidence suggests that reproductive potential and function may be different across racial and ethnic groups. Racial differences have been demonstrated in pubertal timing, infertility, outcomes after assisted reproductive technology (ART ...
Reshef Tal, David B. Seifer
doaj   +1 more source

Clinical characteristics and risk factors of ovarian reserve decreases in women with Crohn’s disease: a case-control study

Journal of Ovarian Research, 2023
Background Crohn’s disease (CD), often occurring in women of child-bearing age, can decline the fertility rate. However, whether it reduces ovarian reserve has been rarely reported.
Peng Xiang, Jia-yin Yao, Xiao-lan Li, Min Zhang, Pin-jin Hu, Min Zhi   +5 more
doaj   +1 more source

Association between individual ovarian dimensions with ovarian reserve indices [PDF]

, 2013
In some young female candidates of assisted reproductive technology (ART), ovarian response to simulative treatments is less than what is expected. More precise assessment of oocyte quality and quantity through studying ovarian dimensions can be useful ...
Berjis, Katayon, Naeini, Elham Hashemian, Neyestanak, Mohammad Zare, Shokoohi, Mostafa   +3 more
core