Results 271 to 280 of about 3,722,377 (405)

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment. [PDF]

Mol Oncol
Cho JG, Hah Y, Yun E, Ka HI, Lee A, Han S, Lee D, Kim SW, Park JH, Kwon BS, Yang Y, Kim J.   +11 more
europepmc   +1 more source

Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade

Cancer immunology research, 2015
R. J. Kelleher, S. Balu-Iyer, Jenni L Loyall, Anthony J. Sacca, Gautam N. Shenoy, P. Peng, V. Iyer, A. Fathallah, C. Berenson, P. Wallace, J. Tario, K. Odunsi, R. Bankert   +12 more
semanticscholar   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Giant Mucinous Borderline Ovarian Tumor With Microinvasion Presenting As Massive Ascites and Acute Respiratory Compromise: A Case Report. [PDF]

Cureus
Flindris S, Styliara E, Galaziou G, Petousis S, Margioula-Siarkou C, Paschopoulos M, Navrozoglou I.   +6 more
europepmc   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Case Report: Cervical cancer masquerading as ovarian tumor: diagnostic challenges in a case with severe pyometra-pyocolpos complex. [PDF]

Front Oncol
Xie C, Liu H, Huang D, Zhao G, Qiu M, Liu Y, Mao D.   +6 more
europepmc   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Identification and characterization of a homozygous deletion found in ovarian ascites by representational difference analysis [PDF]

, 1999
Gabra, H, Morrison, H, Perry, P, Porteous, D J, Rabiasz, G J, Smyth, J F, Taylor, K J, Watson, J E   +7 more
core  

FREQUENCY OF EPITHELIAL OVARIAN TUMOR AND ITS RISK FACTORS AMONG THE PATIENTS PRESENTING WITH OVARIAN TUMOR AT TERTIARY CARE HOSPITAL, KARACHI.

Shazia Naseeb, Haleema Shah
openalex   +2 more sources