Multiscale characterization of ovariectomized rat femur. [PDF]
J Biomech, 2021 Estrogen deficiency activates bone resorbing cells (osteoclasts) and to a lesser extent bone forming cells (osteoblasts), resulting in a gap between resorption and formation that leads to a net loss of bone. These cell activities alter bone architecture and tissue composition.
Liu J +6 more
europepmc +7 more sources
The ameliorative role of specific probiotic combinations on bone loss in the ovariectomized rat model. [PDF]
BMC Complement Med Ther, 2022 Background Osteoporosis, a skeletal disease described by impaired bone strength, cause an increased risk of fractures. We aimed in this study to clarify which particular wise combination of probiotics has the most beneficial effect in the rat model of ...
Gholami A +5 more
europepmc +2 more sources
Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model. [PDF]
Front Endocrinol (Lausanne), 2020 In postmenopausal women, hormonal decline changes muscle function and structure. The non-steroidal selective androgen receptor modulators (SARMs) Ostarine (OS) and Ligandrol (LG) have been shown to increase muscle mass and physical function while showing
Roch PJ +6 more
europepmc +2 more sources
Ovariectomized rat model of osteoporosis: a practical guide. [PDF]
EXCLI J, 2020 Osteoporosis affects about 200 million people worldwide and is a silent disease until a fracture occurs. Management of osteoporosis is still a challenge that warrants further studies for establishing new prevention strategies and more effective treatment
Yousefzadeh N +3 more
europepmc +2 more sources
Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway. [PDF]
Lab Invest, 2021 Angiogenesis plays an important role in damaged organ or tissue and cell regeneration and ovarian development and function. Primary ovarian insufficiency (POI) is a prevalent pathology in women under 40.
Cho J +7 more
europepmc +2 more sources
Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model. [PDF]
Evid Based Complement Alternat Med, 2020 Red clover and hops are already known for their alternative menopausal therapies; however, their combination has not yet been studied. This study aimed to evaluate the efficacy of the combination of red clover and hops extract (RHEC) for treating ...
Kim MR +6 more
europepmc +2 more sources
Placenta-Derived Mesenchymal Stem Cells Restore the Ovary Function in an Ovariectomized Rat Model via an Antioxidant Effect. [PDF]
Antioxidants (Basel), 2020 Oxidative stress is one of the major etiologies of ovarian dysfunction, including premature ovarian failure (POF). Previous reports have demonstrated the therapeutic effects of human placenta-derived mesenchymal stem cells (PD-MSCs) in an ovariectomized ...
Seok J +5 more
europepmc +2 more sources
Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis. [PDF]
Med Sci Monit, 2019 Background Estrogen levels regulate changes in osteoarthritis (OA) by inhibiting degradation of the extracellular matrix. Recent in vitro studies have also shown the role of microRNA-140-5p (miR-140-5p).
Xu X +7 more
europepmc +2 more sources
Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia. [PDF]
Neural Regen Res, 2018 Alzheimer's disease (AD) is associated with oxidative stress, and ultimately results in cognitive deficit. Despite existing literature on the pathophysiology of AD, there is currently no cure for AD.
Kouhestani S, Jafari A, Babaei P.
europepmc +2 more sources
Clinical Epigenetics, 2016 Weight gain is one of the consequences of estrogen deficiency and constitutes a major health problem. The present study highlights the effects of N-methyl pyrrolidone (NMP) on adipogenesis in osteoporosis induced by estrogen deficiency in an ...
Bebeka Gjoksi +4 more
openalex +2 more sources