Selumetinib Treatment in a Neurofibromatosis Type 1 Child With Second Hit Mutation on the NF1 Gene
International Journal of Developmental Neuroscience, Volume 85, Issue 6, October 2025.Initial germline NF1 splice‐site mutation c.3113 + 1G > A followed by tumour‐specific somatic second‐hit mutation c.2033dup (p.Ile679Aspfs*21) exemplifies Knudson's two‐hit hypothesis, driving uncontrolled cell proliferation. ABSTRACT Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder, with plexiform neurofibromas occurring in ...
Song Su +7 more
wiley +1 more source
Anti-Menopausal Effect of Soybean Germ Extract and Lactobacillus gasseri in the Ovariectomized Rat Model. [PDF]
Nutrients, 2023 Lee SH, Lim TJ, Yun EJ, Kim KH, Lim S.
europepmc +1 more source
Effect with time of a norepinephrine synthesis inhibitor (U-14,624) on hypothalamic catecholamine and plasma gonadotrophin concentrations in the ovariectomized rat [PDF]
, 1982 S. Kohn, W. W. Morgan, A.J. Carrillo
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Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]
, 2013 Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
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Effect of Cistanches Herba Aqueous Extract on Bone Loss in Ovariectomized Rat
International Journal of Molecular Sciences, 2011 To assess the ability of traditional Chinese medicine Cistanches Herba extract (CHE) to prevent bone loss in the ovariectomized (OVX) rat, Cistanches Herba extract (CHE) was administered intragastrically to the rats.
H. Liang, Fang Yu, Z. Tong, Z. Huang
semanticscholar +1 more source
The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases
Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.ABSTRACT Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrographolide derivatives have been continuously synthesized and have shown good anti‐inflammatory ...
Xiaoqin Shan +7 more
wiley +1 more source
Changes in polyribosomes and poly(A)-containing polyribosomal RNA in the uterus of the ovariectomized rat in response to oestradiol-17 β treatment [PDF]
, 1980 P.J. Pretorius, Carolus J. Reinecke
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, 2013 The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte.
Bächler, M. +3 more
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Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration
Advanced Science, Volume 12, Issue 33, September 4, 2025.This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li +11 more
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Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective
Journal of Biomedical Materials Research Part A, Volume 113, Issue 9, September 2025.ABSTRACT Implantable medical devices improve quality of life and reduce mortality by restoring the form and function of the human body. Their biomaterial surface components in contact with tissues are, however, susceptible to the host's foreign body response, which drives inflammation and implant fibrous encapsulation.
Nikita Kalashnikov +2 more
wiley +1 more source