Results 211 to 220 of about 1,357,718 (252)

Skeletal alterations in ovariectomized rats

Calcified Tissue International, 1985
Female Sprague Dawley rats were subjected to either bilateral ovariectomy or sham surgery. Tetracycline derivatives were administered to each rat on two separate occasions to label sites of bone formation. All rats were sacrificed at 5 weeks postovariectomy and their proximal tibiae were processed undecalcified for quantitative bone histomorphometry. A
L. A. Ignaszewski, C. C. Walsh, Thomas J. Wronski, P. L. Lowry   +3 more
openaire   +3 more sources

Myocardial contractility in ovariectomized rats

Life Sciences, 1966
Abstract Maximal, isometric, developed tension was measured in isolated papillary muscles from normal and ovariectomized rats. From a comparison of 33 normal rats and 33 ovariectomized rats, there is no evidence to indicate that the development of tension by papillary muscle is altered by ovariectomy.
Herbert L. Kayne, William E. Brodkin
openaire   +3 more sources

Effects of estradiol and estradiol sulfamate on the liver of ovariectomized or ovariectomized and hypophysectomized rats

The Journal of Steroid Biochemistry and Molecular Biology, 2000
Estradiol sulfamate (J995), estradiol-17beta with a substituted sulfamate group in position 3, has much higher systemic estrogenic activity after oral administration than 17beta-estradiol (E2) due to reduced hepatic metabolism of the drug. The lower dose necessary for achievement of adequate systemic estrogenic effects results in a substantial ...
Monica Lindberg, Walter Elger, Gudrun Reddersen, Håkan Eriksson, Sigfrid Schwarz, Bo Freyschuss, Birgitt Schneider, Annemarie Hedden, Lena Sahlin   +8 more
openaire   +3 more sources

The Effect of Etidronate on the Periodontium of Ovariectomized Rats

Journal of Periodontology, 2012
Background: Bisphosphonates are indicated for the treatment of osteoporosis. However, they could have an adverse effect on specific sites, such as the bisphosphonate‐related osteonecrosis of the jaw. The aim of this study is to investigate the effect of etidronate on the resorption and apposition sides of the periodontium in ovariectomized rats.Methods:
Faika Said, Ariane Berdal, Sonia Ghoul-Mazgar, Fathia Khemiss, Blandine Ruhin-Poncet, Hind El Ayeb, Dalila Saidane   +6 more
openaire   +3 more sources

Incadronate inhibits osteoporosis in ovariectomized rats

European Journal of Pharmacology, 2002
Incadronate is a highly effective inhibitor of stimulated bone resorption as demonstrated in a hypercalcemia model in rats, bone metastasis models in mice and rats, and an osteoporosis model in dogs. In this study, the effect of incadronate on osteoporosis in ovariectomized rats was examined.
Koichiro Takahashi, Satoshi Kokubo, Shinji Fukushima, Kyoko Teramura, Takaya Iwai, Kazutoshi Nozaki   +5 more
openaire   +2 more sources

Skeletal Effects of Calcitonin in Ovariectomized Rats*

Endocrinology, 1991
Although calcitonin (CT) has been shown to be effective for the prevention of bone loss in early postmenopausal women, the skeletal effects of the hormone specifically during the early stages of estrogen deficiency have not been characterized histomorphometrically to date.
Thomas J. Wronski, K.W. Burton, Rahul C. Mehta, Patrick P. DeLuca, C.-F. Yen, P. S. Newman, E. E. Soltis   +6 more
openaire   +3 more sources

Cardiovascular Effect of Diosgenin in Ovariectomized Rats

Journal of Medicinal Food, 2019
Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings.
Jand Venes R. Medeiros, Sidney Gonçalo de Lima, José Couras da Silva-Filho, Ilmara Cecilia Pinheiro de Silva Morais, Carla Kelly Barroso Sabino, Lucas A.D. Nicolau, Iris Jordaˆnia Luz Moura, Rita de Cássia Meneses Oliveira, Fabiana de Moura Souza, Aldeídia Pereira de Oliveira   +9 more
openaire   +3 more sources

Antiosteoporotic activity of echinacoside in ovariectomized rats

Phytomedicine, 2013
Echinacoside (ECH), isolated from Cistanche tubulosa (Schrenk) R. Wight stems, has been reported to enhance bone regeneration in MC3T3-E1 cells in vitro. The objectives of this study were to investigate the antiosteoporotic effect of ECH on bone metabolism in the ovariectomized (OVX) rat model of osteoporosis in vivo.Fifty-six aged 6 months female ...
Chun-Feng Zhang, Fei Li, Yanan Yang, Ping Li, Xiaolin Yang, Zhonglin Yang, Changrun Guo   +6 more
openaire   +3 more sources

Estradiol–sertraline synergy in ovariectomized rats

Psychoneuroendocrinology, 2008
This study investigated estradiol (E(2)) modulation of the antidepressant effects of a selective serotonin (5-HT) reuptake inhibitor (SSRI; sertraline) and a tricyclic antidepressant (imipramine) as measured by the forced swim test (FST) followed by assessment of gene and protein expression for the 5-HT transporter (SERT) and multiple 5-HT receptors ...
Sonja J. Stutz, Kathryn A. Cunningham, Rebecca M. Craft, Mary L. Thomas, Stacy L. Sell, Patricia K. Seitz   +5 more
openaire   +3 more sources

Hemorheological effects of secoisolariciresinol in ovariectomized rats

Biorheology, 2016
Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor.We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-related and/or surgical menopause induced by ovariectomy in
Mark B. Plotnikov, Oleg I. Aliev, Anna M. Anishchenko, Nikolay E. Nifantiev, Mikhail Y. Maslov, Tatiana M. Plotnikova   +5 more
openaire   +3 more sources