Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus [PDF]
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria.
Alvarez, Silvia+7 more
core +2 more sources
Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations [PDF]
The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐
Emery, R+5 more
core +1 more source
Conclusions of the French Food Safety Agency on the toxicity of bisphenol A [PDF]
Since more than 10 years, risk assessment of bisphenol A (BPA) is debated at the international level. In 2008, the U.S. National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental ...
Arnich, Nathalie+12 more
core +2 more sources
Mechanical behavior of osteoporotic bone at sub-lamellar length scales [PDF]
Osteoporosis is a disease known to promote bone fragility but the effect on the mechanical properties of bone material, which is independent of geometric effects, is particularly unclear.
Anna eShipov+4 more
core +2 more sources
The "Ram Effect": A "Non-Classical" Mechanism for Inducing LH Surges in Sheep [PDF]
During spring sheep do not normally ovulate but exposure to a ram can induce ovulation. In some ewes an LH surge is induced immediately after exposure to a ram thus raising questions about the control of this precocious LH surge.
A Caraty+85 more
core +5 more sources
Osseointegration of dental implants is affected by osteoporosis. The purpose of this study was overcome the implant failure and facilitate the osseointegration of dental implants by c-myb in ovariectomized (OVX)-induced osteoporosis.
J. Takanche+6 more
semanticscholar +1 more source
Psychoimmunological effects of dioscorea in the ovariectomized rats [PDF]
Address: 1School of Psychology, Chung Shan Medical University, College of Medicine, Taiwan, China, 2Institute of Biochemistry and Biotechnology, Chung Shan Medical University, China, 3Department of Biomedical Sciences, Chung Shan Medical University, China, 4Institute of Immunology, Chung Shan Medical University, China and 5Department of Food and ...
Chun-Wen Cheng+7 more
openaire +3 more sources
The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay [PDF]
The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the ...
Ashby, J+7 more
core +2 more sources
Characteristics of an ovariectomized osteopenic rat model
Abstract Although osteoporosis induced by ovariectomy (Ovx) in the rat has been widely used as a model for postmenopausal osteoporosis in humans, the findings of different investigators are not always consistent. This might be mainly due to differences in the age of the animals at Ovx, time after Ovx, and the variables measured ...
Hikoharu Yamaguchi, Iwao Yamazaki
openaire +3 more sources
Estrogenic effects of silymarin in ovariectomized rats [PDF]
The objective of this study was to test whether silymarin induces changes indicative of estrogenic effects in gonadal organs of ovariectomized (OVX) rats. Silymarin was administered in two experimental groups of OVX rats (n = 7 + 7) for 30 days at the doses of 25 or 50 mg per animal per day. OVX rats (n = 7) receiving 5 µg of 17b-estradiol (E2) for the
Masková J+5 more
openaire +2 more sources