Results 61 to 70 of about 1,357,718 (252)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]

, 2018
Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A., Frick, Karyn M., Hanson, Alicia M., Imhoff, Andrea, Kim, Jaekyoon, Lu, Xingyun, Mackinnon, Alexander Craig, Pandey, Rajesh K., Perera, K. L. Iresha Sampathi, Sem, Daniel S., Sweeney, Noreena, Van Hart, Rochelle M., Wargolet, Adam J.   +12 more
core   +4 more sources

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Estrogenic Potential of Flemingia vestita Benth Tubers in Ovariectomized Rat Model

, 2016
Objective: This study investigates the potential estrogenic activity of the ethanolic extract of Flemingia vestita Benth tubers using ovariectomized rat model. Materials and Methods: The ethanolic extract of F.
S. Shailajan, S. Kumaria, S. Pednekar, S. Menon, Hiranjit Choudhury, Archana Matani   +5 more
semanticscholar   +1 more source

Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats [PDF]

Journal of Steroids & Hormonal Science, 2013
Progesterone (P4) plays a central role in women's health. Synthetic progestins are used clinically in hormone replacement therapy (HRT), oral contraceptives, and for the treatment of endometriosis and infertility. Unfortunately, synthetic progestins are associated with side effects, including cardiovascular disease and breast cancer.
Toh, May Fern, Mendonca, Emma, Eddie, Sharon L., Endsley, Michael P., Lantvit, Daniel D., Petukhov, Pavel A., Burdette, Joanna E.   +6 more
openaire   +5 more sources

Pregnenolone Reduces L‐Dopa‐Induced Dyskinesias in Female Parkinsonian Monkeys

Movement Disorders, EarlyView.
Pregnenolone is the first neurosteroid synthesized from cholesterol in the brain. Ovariectomized female monkeys were tested as a model of women in menopause. They were lesioned with MPTP modeling Parkinson's disease and treated with levodopa (L‐dopa) to induce dyskinesias.
Mélanie Bourque, Marc Morissette, Marco Bortolato, Roberto Frau, Manolo Carta, Thérèse Di Paolo   +5 more
wiley   +1 more source

Effects of Genistein on Inflammasome Induced Pancreatic β‐Cell Apoptosis by Dexamethasone

Molecular Nutrition &Food Research, EarlyView.
The possible mechanism of genistein‐mediated protection against dexamethasone‐induced pancreatic β‐cell apoptosis. Genistein decreases the activation of IRE‐1α, resulting in the reduction of sXBP1, JNK, TXNIP, NLRP3, and IL‐1β expression. Genistein inhibits dexamethasone‐induced pancreatic β‐cell apoptosis.
Nattinee Jitprawet, Jatuporn Sujjitjoon, Petcharee Maneethorn, Namoiy Semprasert, Suwattanee Kooptiwut   +4 more
wiley   +1 more source

Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]

, 1992
We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J., Gratzl, Manfred, Mayerhofer, Artur, Sterzik, K.   +3 more
core   +1 more source

Alfacalcidol enhances collagen quality in ovariectomized rat bones

Journal of Orthopaedic Research, 2014
The aim of this study was to investigate the effects of alfacalcidol (1α(OH)D3: ALF) on bone collagen employing an ovariectomized rat model. Thirty‐five 16‐week‐old female Sprague‐Dawley rats were divided into five groups: SHAM (sham‐operated + vehicle),
H. Nagaoka, M. Terajima, Shizuka Yamada, Y. Azuma, Takayuki Chida, M. Yamauchi   +5 more
semanticscholar   +1 more source

Icariin Promotes Fracture Healing in Ovariectomized Rats

Medical Science Monitor, 2020
BACKGROUND Osteoporotic fractures are common in postmenopausal women and associated with complications. Numerous studies have demonstrated that icariin can be used to treat fractures and osteoporosis. Herein, we evaluated the efficacy of gavage-administered icariin to promote fracture healing in postmenopausal osteoporotic fracture (POF) rats. MATERIAL
Yong Wei, Yong Zhang, Juehua Jing, Bing Han, Jun Li   +4 more
openaire   +3 more sources