Results 171 to 180 of about 25,386 (268)

Understanding risk perception and risk‐reducing decision‐making for surgery among individuals with a genetic predisposition to epithelial ovarian cancer

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
Abstract Genetic predisposition to hereditary breast and ovarian cancer and Lynch syndrome increases the risk of developing cancer, including epithelial ovarian cancer (EOC). Depending on the pathogenic variant, (e.g., BRCA1 or PMS2) the risk of developing EOC ranges from approximately 3%–60%.
Rebekah Kukurudz‐Gorowski, Sylvia Horn, Pascal Lambert, Kim Serfas, Renée El‐Gabalawy, Alon David Altman, Kirk James McManus, Jessica Nicole Hartley, Mark William Nachtigal   +8 more
wiley   +1 more source

Correction: "Betaone" barley water extract suppresses ovariectomy-induced osteoporosis in vivo and RANKL-induced osteoclast differentiation in vitro. [PDF]

PLoS One
Lee Y, Lee HJ, Kim KJ, Shin HB, Shin YA, Jin H, Ham JR, Choi SY, Lee MJ, Lee MK, Son YJ.   +10 more
europepmc   +1 more source

Development and Usability Testing of an Information Needs‐Based Chatbot for Individuals With Pathogenic Variants in BRCA Genes in Korea: A Methodological Study

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
ABSTRACT Korean individuals with BRCA pathogenic/likely pathogenic (P/LP) variants have limited access to genetic counseling due to shortages of genetic professionals and lack of reimbursement. Despite the growing interest in digital health interventions, few digital counseling support tools have been designed to address the diverse information needs ...
Sun‐Young Park, Youlim Kim, Maria C. Katapodi, Sue Kim   +3 more
wiley   +1 more source

Establishment of artificial intelligence-driven fluorescence morphometry reveals involvement of osteocyte perilacunar remodeling specifically in mandibular bone of ovariectomized rats. [PDF]

Microscopy (Oxf)
Nakanishi-Kimura A, Watanabe H, Hoshi-Numahata M, Goseki-Sone M, Iimura T.   +4 more
europepmc   +1 more source

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu, Yi‐Fan Gu, Jian‐Qiao Li, Yi‐Heng Li, Yu‐Hu Chen, Lin‐Hui Wang, Zi‐Ru Wang, Yi‐Cong Wang, Min Yang   +8 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Effect of hypoestrogenism on the alveolar bone and periodontal ligament.

J Indian Soc Periodontol
De La Cruz-Rodriguez R, Mallma-Medina AS, Franco-Quino C, Nguyen H, Aguirre-Siancas EE.   +4 more
europepmc   +1 more source

Impact of estrous cycle, gonadectomy (ovariectomy or castration), and selective G-protein estrogen receptor agonism on inflammatory pain in wild-type mice. [PDF]

Mol Pain
Barnes RC, Alanis A, Quick H, Guindon J.
europepmc   +1 more source

Ultrasound‐Driven Dual Piezocatalytic–Electrical Scaffold Synergistically Promotes Osteoporotic Bone Healing

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT The regeneration of osteoporotic bone defects is severely hampered by compromised endogenous healing capacity, demanding advanced strategies that actively orchestrate pro‐osteogenic microenvironments. Here, we report an integrated, self‐powered osteo‐regenerative system that uniquely leverages a dual ultrasound‐responsive piezoelectric ...
Bing Tan, Jianyuan Ouyang, Yanbo Wen, Li Ren, Guanyin Jiang, Jun He, Jie Hao   +6 more
wiley   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, Volume 7, Issue 4, August 2026.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source