Results 1 to 10 of about 219,205 (349)

Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer.

New England Journal of Medicine, 2019
BACKGROUND Apalutamide is an inhibitor of the ligand-binding domain of the androgen receptor. Whether the addition of apalutamide to androgen-deprivation therapy (ADT) would prolong radiographic progression-free survival and overall survival as compared ...
K. Chi, N. Agarwal, A. Bjartell, B. Chung, A. J. Pereira de Santana Gomes, R. Given, Á. Juárez Soto, A. Merseburger, M. Özgüroğlu, H. Uemura, D. Ye, K. Deprince, V. Naini, Jinhui Li, Shinta Cheng, Margaret K Yu, Ke Zhang, J. Larsen, S. McCarthy, S. Chowdhury   +19 more
semanticscholar   +1 more source

Acute physiological responses to castration-related pain in piglets: the effect of two local anesthetics with or without meloxicam

Animal, 2016
Methods to reduce castration-related pain in piglets are still issues of concern and interest for authorities and producers. Our objectives were to estimate the effectiveness of two protocols of local anesthesia (lidocaine and the combination of ...
C. Bonastre, O. Mitjana, M.T. Tejedor, M. Calavia, A.G. Yuste, J.L. Úbeda, M.V. Falceto   +6 more
doaj   +1 more source

Divergent clonal evolution of castration resistant neuroendocrine prostate cancer

Nature Medicine, 2016
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to absent AR expression and often have neuroendocrine features.
H. Beltran, D. Prandi, J. Mosquera, M. Benelli, L. Puca, J. Cyrta, C. Marotz, Eugenia G. Giannopoulou, B. V. Chakravarthi, S. Varambally, S. Tomlins, D. Nanus, S. Tagawa, E. V. Van Allen, O. Elemento, A. Sboner, L. Garraway, M. Rubin, F. Demichelis   +18 more
semanticscholar   +1 more source

Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer.

New England Journal of Medicine, 2020
BACKGROUND Preliminary trial results showed that enzalutamide significantly improved metastasis-free survival among men who had nonmetastatic, castration-resistant prostate cancer and rapidly increasing prostate-specific antigen (PSA) levels while taking
C. Sternberg, K. Fizazi, F. Saad, N. Shore, U. de Giorgi, D. Penson, U. Ferreira, E. Efstathiou, K. Madziarska, M. Kolinsky, D. Cubero, B. Noerby, F. Zohren, Xun Lin, K. Modelska, J. Sugg, J. Steinberg, M. Hussain   +17 more
semanticscholar   +1 more source

Nonmetastatic, Castration-Resistant Prostate Cancer and Survival with Darolutamide.

New England Journal of Medicine, 2020
BACKGROUND Darolutamide is a structurally distinct androgen-receptor inhibitor that is approved for the treatment of nonmetastatic, castration-resistant prostate cancer.
K. Fizazi, N. Shore, T. Tammela, A. Ulys, E. Vjaters, S. Polyakov, M. Jievaltas, M. Luz, B. Alekseev, I. Kuss, M. Le Berre, O. Petrenciuc, A. Snapir, T. Sarapohja, Matthew R. Smith   +14 more
semanticscholar   +1 more source

Darolutamide in Nonmetastatic, Castration‐Resistant Prostate Cancer

New England Journal of Medicine, 2019
BACKGROUND Darolutamide is a structurally unique androgen‐receptor antagonist that is under development for the treatment of prostate cancer. We evaluated the efficacy of darolutamide for delaying metastasis and death in men with nonmetastatic ...
K. Fizazi, N. Shore, T. Tammela, A. Ulys, E. Vjaters, S. Polyakov, M. Jievaltas, M. Luz, B. Alekseev, I. Kuss, C. Kappeler, A. Snapir, T. Sarapohja, Matthew R. Smith   +13 more
semanticscholar   +1 more source

Enzalutamide in Men with Nonmetastatic, Castration‐Resistant Prostate Cancer

New England Journal of Medicine, 2018
BACKGROUND Men with nonmetastatic, castration‐resistant prostate cancer and a rapidly rising prostate‐specific antigen (PSA) level are at high risk for metastasis.
M. Hussain, K. Fizazi, F. Saad, P. Rathenborg, N. Shore, U. Ferreira, P. Ivashchenko, E. Demirhan, K. Modelska, D. Phung, A. Krivoshik, C. Sternberg   +11 more
semanticscholar   +1 more source

Effects of lidocaine-plus-meloxicam treatment on behavioral and physiological changes, and leukocyte heat shock protein 90 gene expression after surgical castration in Hanwoo bulls

Frontiers in Veterinary Science
This study examined the effects of surgical castration and lidocaine-plus-meloxicam treatment on growth, physiology, behaviors, and leukocyte heat shock protein 90 (HSP 90) gene expression in Hanwoo (Korean cattle) bulls. Twenty Hanwoo bulls (body weight
Ingu Cho, Seonpil Yoo, Da Jin Sol Jung, Jaesung Lee, Seok-Hyeon Baek, Sang Yeob Kim, Jinoh Lee, Dohyun Kim, Hyun Jin Kim, Myunggi Baik, Myunggi Baik   +10 more
doaj   +1 more source

The Effect of Behavioural Indicators of Calf Discomfort Following Routine Procedures on Cow Maternal Care

Animals, 2020
Pain causes altered arousal and specific behaviours that are rare at other times (pain indicators). We examined whether beef cows (mean age 6 years) are sensitive to pain indicators in addition to arousal following ear tagging and rubber ring castration (
Simon P. Turner, Kirstin McIlvaney, Jo Donbavand, Matt J. Turner   +3 more
doaj   +1 more source

Boar taint – possibilities and solutions in pig production [PDF]

Poljoprivreda, 2016
Over many years castration of male pigs has been a common zootechnical practice performed in order to avoid boar taint or offensive odour of pork found in sexually mature boars.
Boris Lukić, Emilija Cimerman, Nikola Raguž, Ivona Djurkin Kušec, Suzanne Rowe, Goran Kušec   +5 more
doaj   +1 more source