Results 11 to 20 of about 86,006 (297)

Castration-resistant prostate cancer cells are addicted to the high activity of cyclin-dependent kinase 2. [PDF]

Mol Oncol
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Chatterjee J, Marin A, Yalala S, Itkonen HM.   +3 more
europepmc   +2 more sources

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone-Sensitive Prostate Cancer. [PDF]

Prostate
ABSTRACT Background Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone‐sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite second‐generation androgen receptor antagonist‐based doublet therapy.
Fujimoto S, Morita T, Yamamoto Y, Inamoto T, Tamura K, Yoshikawa Y, Maenosono R, Takeuchi A, Takahara K, Sugiyama S, Komura K, Yanagisawa T, Fukuokaya W, Kimura T, Fujita K.   +14 more
europepmc   +2 more sources

Delivering an Immunocastration Vaccine via a Novel Subcutaneous Implant

Animals, 2022
Immunocastration relies on the vaccine-mediated stimulation of an immune response to gonadotropin-releasing hormone (GnRH) in order to interrupt spermatogenesis. This approach offers a less painful alternative to traditional castration approaches but the
Andrew K. Curtis, Douglas E. Jones, Michael Kleinhenz, Shawnee Montgomery, Miriam Martin, Mikaela Weeder, Alyssa Leslie, Balaji Narasimhan, Sean Kelly, Drew R. Magstadt, Alfredo Colina, Johann F. Coetzee   +11 more
doaj   +1 more source

Comparison of Flunixin Meglumine, Meloxicam and Ketoprofen on Mild Visceral Post-Operative Pain in Horses

Animals, 2022
The analgesic efficacy of meloxicam and ketoprofen against equine visceral pain is unclear. The aim of this study was to compare the analgesic efficacy of meloxicam (M) and ketoprofen (K) to flunixin meglumine (F) following inguinal castration.
Louise C. Lemonnier, Chantal Thorin, Antoine Meurice, Alice Dubus, Gwenola Touzot-Jourde, Anne Couroucé, Aurélia A. Leroux   +6 more
doaj   +1 more source

Half-castration is a newly effective method for increasing yield and tenderness of male cattle meat [PDF]

Animal Bioscience, 2022
Objective For improving meat quality especially tenderness, male cattle are usually castrated to removes both the testicles. This study was conducted to evaluate the effect castration method (half- and complete-castration) on meat yield and quality ...
Van-Ba Hoa, Dong-Heon Song, Kuk-Hwan Seol, Sun-Moon Kang, Hyun-Wook Kim, Sun-Sik Jang, Soo-Hyun Cho   +6 more
doaj   +1 more source

Nociception-Induced Changes in Electroencephalographic Activity and FOS Protein Expression in Piglets Undergoing Castration under Isoflurane Anaesthesia

Animals, 2022
The objective of this study was to investigate the electroencephalographic reaction pattern and FOS protein expression in male piglets undergoing surgical castration under light isoflurane anaesthesia with or without local anaesthesia. The experiment was
Judith Reiser, Matthias Kreuzer, Julia Werner, Anna M. Saller, Johannes Fischer, Steffanie Senf, Pauline Deffner, Nora Abendschön, Tanja Groll, Andrea Grott, Regina Miller, Shana Bergmann, Michael H. Erhard, Mathias Ritzmann, Susanne Zöls, Gerhard Schneider, Katja Steiger, Christine Baumgartner   +17 more
doaj   +1 more source

The Application of 3D Landmark-Based Geometric Morphometrics towards Refinement of the Piglet Grimace Scale

Animals, 2022
Proper methods of assessment to objectively identify pain are essential for welfare improvements of piglets undergoing surgical castration on commercial farms.
Maria E. Lou, Samantha T. Porter, Jason S. Massey, Beth Ventura, John Deen, Yuzhi Li   +5 more
doaj   +1 more source

Comparison of two doses of ketamine for induction of anaesthesia in ponies undergoing field castration [PDF]

Open Veterinary Journal, 2021
Background: Ketamine-based total intravenous anaesthesia techniques are commonly used in equine practice for ponies requiring short procedures such as castration in field conditions.
Innes K. Wise, Heide Klöppel, Elizabeth A. Leece   +2 more
doaj   +1 more source

Temporal patterns of inflammatory gene expression in local tissues after banding or burdizzo castration in cattle [PDF]

, 2009
peer-reviewedBackground: Castration of male cattle has been shown to elicit inflammatory reactions and acute inflammation is initiated and sustained by the participation of cytokines.
Gath Vivian, Pang, Wanyong, Earley Bernadette, Sweeney, Torres, Sweeney Torres, Earley, Bernadette, Crowe Mark A, Gath, Vivian, Pang Wanyong, Crowe, Mark A   +9 more
core   +1 more source

Ablative radiotherapy in castration-resistant prostate cancer. [PDF]

BJU Int
Objective To prove the oncological benefit of ablative radiotherapy in patients with up to five metastases from castration‐resistant prostate cancer (CRPC) a single‐centre randomised trial was initiated. Patients and Methods This monocentric, randomised, phase II clinical trial enrolled patients with up to five prostate‐specific membrane antigen ...
Hölscher T, Lohaus F, Koi L, Kotzerke J, Hoberück S, Thomas C, Borkowetz A, Löck S, Krause M, Troost EGC.   +9 more
europepmc   +2 more sources