Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.
New England Journal of Medicine, 2020 BACKGROUND We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician's choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had ...
M. Hussain +19 more
semanticscholar +1 more source
Physiology and behavior of pigs before and after castration: effects of two topical anesthetics
Animal, 2010 Surgical castration of male piglets is a common management practice conducted on commercial swine farms to prevent the occurrence of boar taint and aggressive behavior.
M.A. Sutherland +3 more
doaj +1 more source
Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations. [PDF]
, 2017 Cabazitaxel is an effective chemotherapeutic agent used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) refractory to docetaxel.
Hoffman-Censits, Jean, Patel, Sheel
core +3 more sources
Sex Differences in Intestinal Microbial Composition and Function of Hainan Special Wild Boar
Animals, 2020 The gut microbiome plays an important role in the health and disease status of the host. Research on the effect of sex on animal intestinal microorganisms is still limited; and the effect of castration on the gut microbiome of male pigs has not been ...
Xiaozhe Wang +6 more
doaj +1 more source
Animals, 2019 This study assessed the efficacy of pre-operative injected lignocaine and peri-operative topical vapocoolant spray, administered as most practical for incorporation into routine calf castration procedures.
Dominique Van der Saag +4 more
doaj +1 more source
Novel actions of next-generation taxanes benefit advanced stages of prostate cancer. [PDF]
, 2015 PURPOSE: To improve the outcomes of patients with castration-resistant prostate cancer (CRPC), there is an urgent need for more effective therapies and approaches that individualize specific treatments for patients with CRPC.
Berman-Booty, Lisa D. +10 more
core +2 more sources
Loss of testosterone impairs anti-tumor neutrophil function. [PDF]
, 2020 In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role in controlling the growth and spread of malignancies, but whether age- and sex-dependent ...
Arditi, Moshe +9 more
core +1 more source
A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]
, 2017 Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence +6 more
core +1 more source
Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies. [PDF]
, 2020 BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating T-cell repertoire.
Cham, Jason +7 more
core +1 more source
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of prostate carcinoma. [PDF]
, 2016 Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer death among men in the United States. In recent years, several new agents, including cancer immunotherapies, have been approved or are currently being ...
Bander, Neil H +17 more
core +1 more source