Results 41 to 50 of about 55,213 (259)
Jurnal Urologi Indonesia, 2014 Objectives: To demonstrate that intratesticular injection of 20% hypertonic sodium chloride can result in permanent castration and to evaluate serum changes in sodium chloride levels.
Marta Hendry +5 more
doaj +1 more source
Animals, 2021 Castration is one of the most frequently performed surgical procedures in livestock. All methods of castration are associated with a significant degree of pain, affecting the patients’ welfare.
Giulia Guerri +8 more
doaj +1 more source
Advanced Science, EarlyView.P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang +8 more
wiley +1 more source
Healthy Long-Lived Human Beings—Working on Life Stages to Break the Limitation of Human Lifespans
Biology, 2022 The human lifespan has been increasing but will soon reach a plateau. A new direction based on the principal law of lifespan (PLOSP) may enable the human lifespan to be extremely healthy and long by the proper manipulation of the well-defined growing ...
Weikuan Gu
doaj +1 more source
The Journal of Sexual Medicine, 2008 ABSTRACT Introduction A number of men have extreme castration ideations. Many only fantasize about castration; others actualize their fantasies. Aims We wish to identify factors that distinguish those who merely fantasize about being ...
Lesley F, Roberts +3 more
openaire +2 more sources
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Advanced Science, EarlyView.Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An +8 more
wiley +1 more source
Sex-specific effects of a parasite evolving in a female-biased host population
BMC Biology, 2012 Background Males and females differ in many ways and might present different opportunities and challenges to their parasites. In the same way that parasites adapt to the most common host type, they may adapt to the characteristics of the host sex they ...
Duneau David +3 more
doaj +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
Development and Field Validation of Lidocaine-Loaded Castration Bands for Bovine Pain Mitigation
Animals, 2020 Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding.
James W. Saville +11 more
doaj +1 more source