Results 41 to 50 of about 86,006 (297)

No evidence for detrimental effect of chemical castration on working ability in Swiss military dogs [PDF]

, 2019
Hormones influence the social behaviour of dogs. Castration of male dogs induces a reduction of testosterone and has been shown to affect social behaviours associated with aggression and reproduction.
Gfrerer, Nastassja, Taborsky, Michael, Würbel, Hanno   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Economics of boar taint prevention without surgical castration in the pork chain [PDF]

, 2010
An economic analyses of boar taint prevention without surgical castration is lacking. This paper explores currently feasible alternatives to surgical castration along the pork chain.
Backus, G.B.C., Smet, A., de, Valeeva, N.I., Hoste, R., de Smet, A.   +4 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Moving towards boar taint-free meat: an overview of alternatives to surgical castration from a chain perspective [PDF]

, 2009
The objective of this study is to review important issues in boar taint prevention without surgical castration, namely alternatives to surgical castration, factors influencing boar taint development and economic considerations associated with the ...
Backus, G.B.C., Valeeva, N.I., Baltussen, W.H.M.   +2 more
core  

Castration of lambs: a welfare comparison of different castration techniques in lambs over 10 weeks of age

, 2007
Seventy male lambs over 10 weeks of age were castrated using Burdizzo, rubber rings, or surgery to assess the acute and long-term effects of castration. All castrations were performed under local anaesthesia.
Doherr, Marcus G, Susanne Melches, Steiner, Adrian, Sibylle C. Mellema, Mellema, Sibylle C, Beat Wechsler, Marcus G. Doherr, Melches, Susanne, Wechsler, Beat, Adrian Steiner   +9 more
core   +1 more source

Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer. [PDF]

, 2023
The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies.
Shrimp, Jonathan H, Maisiak, M, Gestwicki, JE, Nisbet, Ian, Jonathan H Shrimp, Ralph, SJ, Jason E Gestwicki, Murali Krishna Cherukuri, Cherukuri, Murali Krishna, Cherukuri, MK, Shrimp, JH, Marisa Maisiak, Neckers, Leonard M, Maisiak, Marisa, Genesis M Rivera-Marquez, Oleta T Johnson, Ishida, R, Johnson, OT, Echtenkamp, FJ, Rivera-Marquez, Genesis M, Ryo Ishida, Leonard M Neckers, Ishida, Ryo, Sinha, Arnav, Rivera-Marquez, GM, Ralph, Stephen John, Gestwicki, Jason E, Echtenkamp, Frank J, Johnson, Oleta T, Frank J Echtenkamp, Sinha, A, Stephen John Ralph, Ian Nisbet, Nisbet, I, Arnav Sinha, Neckers, LM   +35 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Impact of castration with or without alpha-tocopherol supplementation on the urethral sphincter of rats

International Brazilian Journal of Urology, 2012
OBJECTIVE: To analyze the impact of low levels of testosterone induced by orchiectomy and the effect of alpha-tocopherol supplementation on oxidative stress in the urethral sphincter.
Mirian Kracochansky, Leonardo Oliveira Reis, Fabio Lorenzetti, Valdemar Ortiz, Miriam Dambros   +4 more
doaj   +1 more source