Results 51 to 60 of about 77,635 (307)
Castration as Part of Reindeer Herd Management [PDF]
, 2022 It has been suggested that reindeer castration is a practice that started very early in the process of reindeer domestication. Castrated males have long been favoured as working animals, and have been used for the transport of people and goods ...
van den Berg, Mathilde +3 more
core +1 more source
Advanced Science, EarlyView.A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo +13 more
wiley +1 more source
Healthy Long-Lived Human Beings—Working on Life Stages to Break the Limitation of Human Lifespans
Biology, 2022 The human lifespan has been increasing but will soon reach a plateau. A new direction based on the principal law of lifespan (PLOSP) may enable the human lifespan to be extremely healthy and long by the proper manipulation of the well-defined growing ...
Weikuan Gu
doaj +1 more source
The Journal of Sexual Medicine, 2008 ABSTRACT Introduction A number of men have extreme castration ideations. Many only fantasize about castration; others actualize their fantasies. Aims We wish to identify factors that distinguish those who merely fantasize about being ...
Lesley F, Roberts +3 more
openaire +2 more sources
, 2013 BACKGROUND: Median overall survival (OS) in men with metastatic castration-resistant prostate cancer (CRPC) was 13-16 mo in the predocetaxel era. Prognostic nomograms for survival estimation in CRPC were constructed prior to the introduction of docetaxel
Pezaro, Carmel +12 more
core +1 more source
Advanced Science, EarlyView.A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu +15 more
wiley +1 more source
Surgical Castration in Hormone-Refractory Metastatic Prostate Cancer Patients Can Be an Alternative for Medical Castration [PDF]
, 2012 Background. Most patients with metastatic prostate cancer are endocrinologically treated with LHRH agonist, but finally castration-refractory and hormone-refractory cancers occur.
Sadao Imao +7 more
core +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Sex-specific effects of a parasite evolving in a female-biased host population
BMC Biology, 2012 Background Males and females differ in many ways and might present different opportunities and challenges to their parasites. In the same way that parasites adapt to the most common host type, they may adapt to the characteristics of the host sex they ...
Duneau David +3 more
doaj +1 more source
[Castration of calves: a survey among Swiss suckler beef farmers]
, 2006 In fall 2004, a survey of a representative sample of 1185 Swiss suckler beef farmers was carried out by questionnaire (return rate 51.9%). 32.7% of the respondents castrated their calves without the help of a veterinarian, 37.8% mandated a veterinarian ...
Boesch, Daniel +2 more
core +1 more source