Results 51 to 60 of about 86,006 (297)

Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics

Vaccines, 2021
Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical functions in the body. There are markedly conflicting findings in the literature regarding the bimodal effects of NO in carcinogenesis and tumor progression,
Joel Mintz, Anastasia Vedenko, Omar Rosete, Khushi Shah, Gabriella Goldstein, Joshua M. Hare, Ranjith Ramasamy, Himanshu Arora   +7 more
doaj   +1 more source

Renal phenotype of Et-1 transgenic mice is modulated by androgens

European Journal of Medical Research, 2009
Introduction Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarring.
Kalk P, Thöne-Reineke C, Schwarz A, Godes M, Bauer C, Pfab T, Hocher B   +6 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

INTRATESTICULAR INJECTION OF 20% HYPERTONIC SODIUM CHLORIDE AS A NOVEL CASTRATION METHOD: A PRECLINICAL STUDY

Jurnal Urologi Indonesia, 2014
Objectives: To demonstrate that intratesticular injection of 20% hypertonic sodium chloride can result in permanent castration and to evaluate serum changes in sodium chloride levels.
Marta Hendry, Sunaryo Hardjowijoto, Basuki B Purnomo, Endang Joewarini, Dewa Ketut Meles, Widodo J P   +5 more
doaj   +1 more source

The Clinical Effect of Xylazine Premedication in Water Buffalo Calves (Bubalus bubalis) Undergoing Castration under General Anaesthesia

Animals, 2021
Castration is one of the most frequently performed surgical procedures in livestock. All methods of castration are associated with a significant degree of pain, affecting the patients’ welfare.
Giulia Guerri, Ilaria Cerasoli, Paola Straticò, Ippolito De Amicis, Brunella Giangaspero, Vincenzo Varasano, Andrea Paolini, Augusto Carluccio, Lucio Petrizzi   +8 more
doaj   +1 more source

A Passion for Castration: Characterizing Men Who Are Fascinated with Castration, but Have Not Been Castrated

The Journal of Sexual Medicine, 2008
ABSTRACT Introduction A number of men have extreme castration ideations. Many only fantasize about castration; others actualize their fantasies. Aims We wish to identify factors that distinguish those who merely fantasize about being ...
Lesley F, Roberts, Michelle A, Brett, Thomas W, Johnson, Richard J, Wassersug   +3 more
openaire   +2 more sources

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Healthy Long-Lived Human Beings—Working on Life Stages to Break the Limitation of Human Lifespans

Biology, 2022
The human lifespan has been increasing but will soon reach a plateau. A new direction based on the principal law of lifespan (PLOSP) may enable the human lifespan to be extremely healthy and long by the proper manipulation of the well-defined growing ...
Weikuan Gu
doaj   +1 more source

Improved survival in a cohort of trial participants with metastatic castration-resistant prostate cancer demonstrates the need for updated prognostic nomograms.

, 2013
BACKGROUND: Median overall survival (OS) in men with metastatic castration-resistant prostate cancer (CRPC) was 13-16 mo in the predocetaxel era. Prognostic nomograms for survival estimation in CRPC were constructed prior to the introduction of docetaxel
Pezaro, Carmel, Omlin, Aurelius, Thompson, Emilda, Sandhu, Shahneen, Maier, Gal, de Bono, Johann, Attard, Gerhardt, Bianchini, Diletta, Olmos, David, Ferraldeschi, Roberta, Parker, Chris, Mukherji, Deborah, Mulick Cassidy, Amy   +12 more
core   +1 more source

Acute and chronic pain in calves after different methods of rubber-ring castration [PDF]

, 2012
The goal of the present study was to evaluate the effect of different methods of rubber-ring castration on acute and chronic pain in calves. Sixty-three 4-6 week-old calves were randomly and sequentially allocated to one of five groups: Group RR ...
Bruckmaier, Rupert M., Becker, Johanna, Steiner, Adrian, Zanolari, Patrik, Doherr, Marcus G., Bodmer, Michèle   +5 more
core   +1 more source