Results 51 to 60 of about 219,205 (349)

Hematologic Toxicity of Concurrent Administration of Radium-223 and Next-generation Antiandrogen Therapies. [PDF]

, 2017
PURPOSE/OBJECTIVES: Radium-223 is a first-in-class radiopharmaceutical recently approved for the treatment of castration-resistant prostate cancer in patients with symptomatic bone metastases.
Basch, Beer, Chen, Cookson, De Bono, Den, Dreicer, Fizazi, Hoskin, Kantoff, Keizman, Morris, Nilsson, Nilsson, Parker, Petrylak, Ryan, Scher, Siegel, Tannock, Tu   +20 more
core   +2 more sources

Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles. [PDF]

, 2016
Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading cause of cancer-related death for American men due to a subset of patients progressing to lethal and incurable metastatic castrate-resistant prostate cancer (CRPC).
Hoang, David T., Iczkowski, Kenneth A., Kilari, Deepak, Nevalainen, Marja T., See, William   +4 more
core   +2 more sources

Review of Eunuchs and Castrati: Disability and Normativity in Early Modern Europe by Katherine Crawford

Disability Studies Quarterly, 2021
No abstract available.
Turnip Van Dyke
doaj   +1 more source

Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial

The Lancet Oncology, 2019
Summary Background Metastatic castration-resistant prostate cancer is enriched in DNA damage response (DDR) gene aberrations. The TOPARP-B trial aims to prospectively validate the association between DDR gene aberrations and response to olaparib in ...
J. Mateo, N. Porta, D. Bianchini, U. McGovern, T. Elliott, Robert J. Jones, I. Syndikus, C. Ralph, Suneil Jain, M. Varughese, O. Parikh, S. Crabb, A. Robinson, D. McLaren, A. Birtle, J. Tanguay, S. Miranda, I. Figueiredo, G. Seed, C. Bertan, P. Flohr, Berni Ebbs, P. Rescigno, G. Fowler, A. Ferreira, R. Riisnaes, Rita Pereira, A. Curcean, R. Chandler, M. Clarke, B. Gurel, M. Crespo, Daniel Nava Rodrigues, S. Sandhu, A. Espinasse, P. Chatfield, N. Tunariu, W. Yuan, E. Hall, S. Carreira, J. D. de Bono   +40 more
semanticscholar   +1 more source

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Cells, 2018
Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and benign. Due to its high prevalence, it is, however, still the second most common cause of death by cancer in men in the West.
Jens Staal, Rudi Beyaert
doaj   +1 more source

Reasons for and Behavioral Consequences of Male Dog Castration—A Questionnaire Study in Poland

Animals, 2022
In many Western countries, castration is the most popular surgical desexing procedure in dogs. The aim of the study was to identify the reasons for male dog castration and to determine the owners’ perceptions about changes in dog behavior before and ...
Marcelina Kriese, Ewelina Kuźniewska, Andrzej Gugołek, Janusz Strychalski   +3 more
doaj   +1 more source

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

How Well Does Australian Animal Welfare Policy Reflect Scientific Evidence: A Case Study Approach Based on Lamb Marking

Animals, 2023
The development and substance of animal welfare policy is subject to a range of social, cultural, economic, and scientific influences that commonly vary within and between countries.
Charlotte H. Johnston, Vicki L. Richardson, Alexandra L. Whittaker   +2 more
doaj   +1 more source

The molecular basis for ethnic variation and histological subtype differences in prostate cancer. [PDF]

, 2013
Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China.
Goldstein, Andrew S, Huang, Jiaoti, Zong, Yang   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source