Results 131 to 140 of about 251,258 (312)

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Microbiota profile in organs of the horseflies (Diptera: Tabanidae) in Northeastern China

Frontiers in Microbiology
Tabanids, commonly known as horseflies and belonging to the family Tabanidae, are blood-feeding arthropods (BFA) found worldwide. They are known for their ability to mechanically and biologically transmit various animal pathogens.
Hong-Yu Qiu, Hong-Yu Qiu, Qing-Bo Lv, Chun-Ren Wang, Hao Ju, Chun-Feng Luo, Shun-Shuai Liu, Mu-Han Na, Qiao-Cheng Chang, Jia-Fu Jiang   +9 more
doaj   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Time course changes in in vivo muscle mechanical function and Ca2+ regulation of force following experimentally induced gradual ovarian failure in mice

Experimental Physiology
The abrupt cessation of ovarian hormone release is associated with declines in muscle contractile function, yet the impact of gradual ovarian failure on muscle contractility across peri‐, early‐ and late‐stage menopause remains unclear.
Avery Hinks, Benjamin E. Dalton, Parastoo Mashouri, Luke D. Flewwelling, William Glen Pyle, Arthur J. Cheng, Geoffrey A. Power   +6 more
doaj   +1 more source

Prediction of a poor ovarian response in assisted reproductive technology programs in patients after surgical interventions on the ovaries

Бюллетень сибирской медицины
The aim. To conduct a comparative analysis of clinical and anamnestic data in women of reproductive age after ovarian cyst surgery and with occult premature ovarian insufficiency (POI) to predict a poor ovarian response to stimulation.Materials and ...
M. L. Dmitrieva, I. A. Petrov, O. A. Tikhonovskaya, S. V. Logvinov, O. M. Duma, Z. O. Kosimova, M. A. Chernyshova, S. Y. Yuriev, O. S. Timofeeva, A. A. Zhdankina, A. V. Gerasimov   +10 more
doaj   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Long non-coding RNA Loc105611671 promotes the proliferation of ovarian granulosa cells and steroid hormone production upregulation of CDC42

Frontiers in Veterinary Science
Granulosa cells (GCs) are essential for follicular development, and long non-coding RNAs (LncRNAs) are known to support the maintenance of this process and hormone synthesis in mammals.
Jinglei Wang, Hanying Chen, Yongsheng Zhang, Hong Shen, Xiancun Zeng   +4 more
doaj   +1 more source

A Case of Cerebral Cortical Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
Sixiao Liu, Kunqian Ji, Wei Wu, Wei Li
wiley   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

Selenium Content of the Gonads of the Domestic Dog (Canis lupus f. familiaris) in Relation to Sex, Age, and Reproductive Disorders

Animals
Appropriate selenium (Se) levels contribute to the weakening of the effects of cellular peroxidation and have a protective function, ensuring the effectiveness of the defense against various diseases.
Ewa Skibniewska, Marta Kołnierzak, Bartosz Skibniewski, Iwona Lasocka, Michał Skibniewski   +4 more
doaj   +1 more source