Results 251 to 260 of about 162,204 (317)

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

A Decline in Follicle Cell Function Is a Major Driver of Drosophila Ovarian Aging. [PDF]

Aging Cell
Wolfgram EA, Nystul TG.
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling. [PDF]

Front Endocrinol (Lausanne)
Fallata A, Nahdi S, Alamri HS, Barhoumi T, Alanazi M, Rahman MA, Alwasel S, Harrath AH.   +7 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

HDAC3 Preserves the primordial follicle reserve by epigenetically suppressing ferroptosis in pregranulosa cells. [PDF]

Cell Mol Life Sci
Chen Z, Guo J, Gao M, Wang H, Cai H, Yang Q, Yang X, Lin Y, Zhu Z, Qin S, Bao Y, Zhao T, Liu L, Wang T, Zhou B, Zhang H, Wang J, Guo H, Xia G, Wang C.   +19 more
europepmc   +1 more source

Expanding High‐Fidelity Multiplexing in Ultrasensitive Single‐Molecule Protein Detection via Proximity Barcoding

Angewandte Chemie, EarlyView.
We develop an ultrasensitive, high‐accuracy multiplex protein detection platform integrating high‐throughput single‐molecule protein detection with proximity ligation. Using paired DNA barcodes, this platform breaks the digital immunoassay multiplexing ceiling imposed by cross‐reactivity and fluorescence spectral overlap, providing a broadly accessible
Chi‐Chia Wang, Emily Dorsey, Connie Wu
wiley   +1 more source

Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells. [PDF]

Eur J Histochem
Su H, Ma R, Su D, Tan C, Zhu Y, Yang X.
europepmc   +1 more source

VDR-Spermidine Axis Protects Against Age-Related Granulosa Cell Dysfunction and Follicular Decline via DNMTs-Mediated p53 Methylation. [PDF]

Int J Biol Sci
Chen H, Geng Q, Wang Q, Li Y, Shangguan L, Zhu Z, Zhang J, Wang S, Chen X, Shen S, Wen Y, Wang D, Wang Y.   +12 more
europepmc   +1 more source

Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS. [PDF]

FASEB J
Weng Y, Shangguan L, Shen Q, Zhu Z, Zhang Y, Zhang J, Yan G, Shen S, Xiang Z, Ruan J, Wen Y, Wang D, Wang Y.   +12 more
europepmc   +1 more source