Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Mesonephric-like Adenocarcinoma of the Ovary: Clinicopathological and Molecular Characteristics [PDF]
, 2022 Hyun Hee Koh +2 more
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Glucose Intolerance in a Large Cohort of Mediterranean Women With Polycystic Ovary Syndrome [PDF]
, 2004 Alessandra Gambineri +7 more
openalex +1 more source
Maturation, Spawning Period, and Fecundity of the White Crappie, Pomoxis annularis Rafinesque, in Beaver Reservoir, Arkansas [PDF]
, 1981 Gonosomatic indices and ovum diameter frequency distributions showed that the Beaver Reservoir white crappie spawns from late April through May. During the spawning season females release eggs more than once.
Kilambi, Raj V., Thomas, Janet L.
core +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Normal gestations and live births after orthotopic autograft of vitrified–warmed hemi-ovaries into ewes [PDF]
, 2005 Agnès Bordes +6 more
openalex +1 more source
Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS : a systematic review [PDF]
, 2014 Peer reviewedPublisher ...
Colleran, Rebecca +5 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source