Results 101 to 110 of about 517,167 (367)

RFRP3 influences basal lamina degradation, cellular death, and progesterone secretion in cultured preantral ovarian follicles from the domestic cat. [PDF]

, 2019
The hypothalamic neuropeptide RFRP3 can suppress hypothalamic GnRH neuron activation and inhibit gonadotropin release from the anterior pituitary. RFRP3 is also produced locally in the ovary and can inhibit steroidogenesis and follicle development in ...
Bentley, George, Comizzoli, Pierre, Wilsterman, Kathryn   +2 more
core   +1 more source

Expression of the neural cell adhesion NCAM in endocrine cells of the ovary [PDF]

, 1991
In the adult mammalian ovary morphogenesis and differentiation processes are under hormonal control and, thus, occur in a highly regulated way during the sexual cycle.
Gratzl, Manfred, Lahr, G., Mayerhofer, Artur   +2 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Low‐grade serous carcinoma detected from intraoperative peritoneal washings: Cytological findings and detection of KRAS mutation

Cancer Reports, 2022
Background Low‐grade serous carcinoma (LGSC) of the ovary, which is extremely rare tumor, has better prognosis than high‐grade serous carcinoma (HGSC). Genetic backgrounds of those are different, so that LGSC usually shows KRAS or BRAF mutation, whereas ...
Eriko Yamamoto, Kenji Warigaya, Yuichi Kinoshita, Ayana Yamamoto, Shin‐ichi Murata   +4 more
doaj   +1 more source

Standardized network reconstruction of CHO cell metabolism [PDF]

arXiv, 2013
We have created a genome-scale network reconstruction of chinese hamster ovary (CHO) cell metabolism. Existing reconstructions were improved in terms of annotation standards, to facilitate their subsequent use in dynamic modelling. The resultant network is available from ChoNet (http://cho.sf.net/).
arxiv  

Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome. [PDF]

, 2019
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-aged women that is comprised of two out of the following three features: hyperandrogenism, oligo- or amenorrhea, or polycystic ovaries. In addition to infertility, many women
Arroyo, Pablo, Ho, Bryan S, Kelley, Scott T, Sau, Lillian, Thackray, Varykina G   +4 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Using serum CA125 to assess the activity of potential cytostatic agents in ovarian cancer [PDF]

, 2015
Objective: New strategies are required to rapidly identify novel cytostatic agents before embarking on large randomized trials. This study investigates whether a change in rate of rise (slope) of serum CA125 from before to after starting a novel agent ...
Ann Petruckevitch, Charlie Gourley, Coleman, Desai, Diana E. Kornbrot, Eisenhauer, Gordon J. Rustin, Gore, Hurteau, Jamie S. Morgan, Joanna Pascoe, Liu, Marcia R. Hall, Markman, Mojca Persic, Nick Stuart, Perez-Gracia, Rustin, Rustin, S. Michael Crawford, Saad Tahir, Wendi Qian   +21 more
core   +1 more source

Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice [PDF]

, 2020
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility.
Amicarelli, F, Cristiano, L, D'Alessandro, AM, Emidio, GD, Falone, S, Nottola, S, Palmerini, MG, Placidi, M, Rea, F, Rossi, G, Tatone, C   +10 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source