Results 71 to 80 of about 893,568 (343)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Associations between forkhead box l2 expression and ovary development in laying hens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
Make sure healthy ovary or follicle is critical for extending egg laying performance in poultry. Transcription factor forkhead box L2 (FOXL2) gene have key role in regulate development of ovary.
Shouping ZHANG, Xiaojing XIA, Lirong WANG, Renfeng LI, Meng YANG, Sanhu WANG   +5 more
doaj   +1 more source

Single-cell reconstruction of follicular remodeling in the human adult ovary

Nature Communications, 2019
The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus. The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian tissue homeostasis, remain elusive.
X. Fan, M. Białecka, Ioannis Moustakas, E. Lam, V. Torrens-Juaneda, N. V. Borggreven, L. Trouw, L. Louwé, G. Pilgram, H. Mei, L. V. D. Westerlaken, S. Lopes, S. Lopes   +12 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Polycystic Ovary Syndrome (PCOS): Making Sense of the Alphabet

Journal of the Dow University of Health Sciences, 2011
PCOS is the commonest endocrinopathy of reproductive yearswith a quoted prevalence of 5-11%, depending uponpopulations studied.1 Despite being a liberally diagnosed, thedisorder remains relatively poorly understood.
Lubna Pal
doaj  

Effect of Metformin Therapy on Clinical and Hormonal Indices of Patients with Polycystic Ovary Syndrome [PDF]

, 2021
Sara Inayat, H. F. Khattak, Maryam Muhammad, K. Robeen, Asad Inayat, Fatima Fatima   +5 more
openalex   +1 more source

Primordial follicular assembly in humans : revisited [PDF]

, 2009
Peer ...
A. Maheshwari, Baker, Donovan, Gumienny, Konishi, P. A. Fowler, Pinkerton, Satoh, Vaskivuo   +8 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats [PDF]

, 2012
We investigated the effects of different windows of testosterone propionate (TP) treatment during foetal and neonatal life in female rats to determine whether and when excess androgen exposure would cause disruption of adult reproductive function ...
Abbott, Abbott, Abbott, Alan S McNeilly, Amanda J Drake, Anderson, Anderson, Baravalle, BARRACLOUGH, Beloosesky, BRAWER, Brawer, Carretero, Champagne, Childs, Durlinger, Faiman, Franks, Grossmann, Hillier, HIRSHFIELD, Hoepfner, Honnma, Levallet, Marie Broyde, McNeilly, Michelle Welsh, Misugi, Murray, Nelson, Nelson, Nilsson, Ota, Pepling, Pepling, Picon, Rey, Richard Sharpe, Roma, Rossetti, Scalzo, Schindler, Slob, Tetsuka, Victoria Tyndall, Webber, Welsh, Welsh, Wolf, Xia, Yan   +50 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source