Results 201 to 210 of about 75,003 (271)

Assessing Risk for Bycatch and Byproduct Species Using a Modified Sustainability Assessment for Fishing Effects (SAFE) Approach

Fish and Fisheries, EarlyView.
ABSTRACT Central to ecosystem‐based fisheries management is ensuring the sustainability of bycatch and byproduct species. However, the sustainability of these species is difficult to assess as the lack of information limits the use of traditional stock assessment methods.
Grant J. Johnson, Jonathan J. Smart, Vinay Udyawer, Rik C. Buckworth, Clive R. McMahon, Chalie Huveneers   +5 more
wiley   +1 more source

All roads lead to ROME: convergence of evidence in precision oncology. [PDF]

ESMO Open
Subbiah V.
europepmc   +1 more source

The ribosome‐associated complex regulates cytosolic translation upon mitoprotein‐induced stress

The FEBS Journal, EarlyView.
Defects in mitochondrial protein import trigger a stress response. The contribution of translation regulation to such a response is only partially understood. We demonstrate that the deletion of mitochondrial surface proteins (TOM70/TOM71) leads to defects in mitochondrial biogenesis and slow growth.
Jiaxin Qian, Annika Nutz, Katja Hansen, Lea Bertgen, Mirita Franz‐Wachtel, Boris Macek, Johannes M. Herrmann, Doron Rapaport   +7 more
wiley   +1 more source

When the gatekeeper falls: developmental vulnerability of the thalamic reticular nucleus in neonatal and pediatric hypoxic-ischemic brain injury. [PDF]

Front Syst Neurosci
Hsiao K.
europepmc   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Effects of a Twelve-Week Complementary Sports Program to Athletics Training on Motor Competence in Children Aged 6 to 10 Years Old-A Study Protocol. [PDF]

Healthcare (Basel)
Lopes N, Jacinto M, Monteiro D, Matos R, Ibáñez SJ.   +4 more
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Power management and performance optimization of underwater wireless sensor networks based on MARL. [PDF]

PLoS One
Guan J.
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source