Results 141 to 150 of about 13,193,526 (310)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
From vision to reality, transforming PK-12 education in Ohio
, 2008 Electronic coverage as of Dec. 23, 2009: 2006/2007-; Some reports also have a distinctive title.; Latest issue consulted: 2007/2008.; Description based on: 2006/2007; title from PDF cover (viewed on Dec. 23, 2009)
Ohio. State Board of Education.
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Kansas state plan for vocational education for fiscal years 1995-1996
, 1994 "Application for Federal Funds Carl D. Perkins Vocational and Applied Technology Education Act Amendments of 1990 P.L. 100-392." "Draft." "February 8, 1994.""The Kansas State Plan/or Vocational Education for Fiscal ...
Kansas. State Board of Education.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Detecting GenAI assistance in programming assessments with over-uniqueness and sample matching
Discover ComputingIn engineering education, Generative Artificial Intelligence (GenAI) might be misused to complete assessments with limited understanding. On courses that allow the use of GenAI, students might also forget to acknowledge its assistance. There is a need to
Oscar Karnalim +5 more
doaj +1 more source
Education, over-education and wage inequality : evidence for Spain [PDF]
, 2005 In this paper we use the European Community Household Panel to explore the connection between education, over-education, and wage-inequality in Spain for the period 1994-2001. Our central approach is based on quantile regression. We find that higher education is associated with higher wage dispersion.
Ana I Moro-Egido, Santiago BudrÌa
openaire +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source