Results 91 to 100 of about 15,088 (297)
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Psychiatric and neurodevelopmental diagnoses in adolescence and adulthood over-indebtedness among Finns born in 1987. [PDF]
Eur J Public Health, 2022 Hiilamo A +4 more
europepmc +1 more source
Personal Bankruptcy Law, Fresh Starts, and Judicial Practice [PDF]
We explore the ways French judges respond to the possibility of discharging personal debts in exchange for liquidation of debtors’ assets. We present empirical results on the determinants of judicial selection between debtors whose debts are wiped out ...
Bertrand Chopard +3 more
core
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
Advanced Science, EarlyView.A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
PERSONAL BANKRUPTCIES FROM MACROECONOMIC PERSPECTIVE
International Journal of Entrepreneurial Knowledge, 2017 Personal bankruptcies are traditionally discussed from legal, microeconomic or social point of view. This paper focuses on the development of personal bankruptcies in the Czech Republic during the time period 2008-2016 and aims to connect performance of
Jan KUBÁLEK +2 more
doaj +1 more source
Corporate risks, risk bearing ability and equity [PDF]
, 2011 There is a relation between corporate risks, risk bearing ability and equity. In order to assess the risk bearing ability of a corporation, one reference figure is equity, understood as the sum of legal capital and reserves, free reserves and accrued ...
Handschin, Lukas
core
Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
Advanced Science, EarlyView.Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun +5 more
wiley +1 more source
Moneta e Credito, 2013 Nelle osservazioni dell'economia mentre si muoveva verso il grande crollo dell'inverno del 1932-33 ,sono rivelati gli elementi di ciò che accade quando il sistema di mercato si rompe . Il lavoro esamina gli interventi di successo degli anni 1960 e '70 ,
H.P. MINSKY
doaj +1 more source
An Impact Analysis of Microfinance in Bosnia and Herzegovina [PDF]
, 2007 This paper applies the financing constraint approach to study whether microfinance institutions improved access to credit for microenterprises in Bosnia and Herzegovina.
Hartarska, Valentina, Nadolnyak, Denis
core +1 more source