Results 111 to 120 of about 2,504,262 (302)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evaluation of Community Pharmacists Performance in Management of Cough, Diarrhea and Common Cold using OTC Medication Requests in Hamadan in 2015

پزشکی بالینی ابن سینا, 2016
Introduction & Objective: Pharmacists usually encounter requests for over the counter drugs. How a pharmacist performs in evaluating patientschr('39') signs and symptoms, treating them, and moreover his or her approach in prescribing over the counter ...
A. Rashidi, S. Ataei, J. Poorolajal, F. Zeaati   +3 more
doaj  

A degree map on unimodular rows [PDF]

, 2012
We associate to any endomorphism of the punctured affine space over some field an element in the Witt group of the base field that we call degree. We use this degree to give a counter-example to a question on unimodular rowsComment: Final version; J ...
Fasel, Jean
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Comparative Study on The Reasons for Use and Non-Use of Self-Medication Among Students of a Medical College in Western Uttar Pradesh

National Journal of Community Medicine, 2016
Background: Self-medication is selection and use of non-prescription medicines by individuals’ own initiatives to treat self-recognized illnesses or symptoms.
Shyam B Gupta , Danish Imtiaz, Ved Prakash Shrotriya, Atul Kumar Singh   +3 more
doaj  

Unveiling pedagogical effects of blended multimedia and slide-based approaches on students’ self-efficacy and performance in over-the-counter medication counseling: an explanatory mixed methods study

BMC Medical Education
Background Addressing healthcare communication skills through a multimedia approach may enrich undergraduate pharmacy students’ medication counseling competence.
Yen-Ming Huang, Fang-Ju Lin, Yao-Hsing Wang, Olayinka Shiyanbola, Hsun-Yu Chan, Yunn-Fang Ho   +5 more
doaj   +1 more source

Effect of angular inflow on the vibratory response of a counter-rotating propeller [PDF]

This report presents the results of a propeller vibratory stress survey on the Fairey Gannet aircraft aimed at giving an assessment of the difference in vibratory response between single and counter-rotating propeller operation in angular inflow.
Brown, P. C., Turnberg, J. E.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Alternative remedies for insomnia: a proposed method for personalized therapeutic trials

Nature and Science of Sleep, 2017
Kate Romero,1,2 Balaji Goparaju,1,2 Kathryn Russo,1,2 M Brandon Westover,1 Matt T Bianchi1,2 1Neurology Department, Massachusetts General Hospital, 2Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA Abstract: Insomnia is a common ...
Romero K, Goparaju B, Russo K, Westover MB, Bianchi MT   +4 more
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