Results 91 to 100 of about 502,761 (308)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Study of self-medication status among referring patients to Kashan pharmacies

Journal of Pharmacoeconomics and Pharmaceutical Management, 2015
Background: Self-medication is one of the largest social, economic and health problems in developing communities such as Iran. It is considered as an unsafe treatment behavior.
Hadi Hayati, Bahman Khosravi, Abbas Kebriaeezadeh, Mahdi Khanizade   +3 more
doaj  

The Risks of “Getting High” on Over-the-Counter Drugs during Pregnancy

Scientia Pharmaceutica
Easy access to over-the-counter (OTC) drugs makes it possible to procure active substances that normally used in therapeutic doses do not raise health problems.
Bianca-Eugenia Ősz, Ruxandra Ștefănescu, Andreea Sălcudean, George Jîtcă, Camil-Eugen Vari   +4 more
doaj   +1 more source

Prescription Drugs Online [PDF]

, 2004
Presents findings from a survey conducted in May and June 2004. Looks at issues of convenience and trust in purchasing prescriptions online, drug-related spam, and future ...
Susannah Fox
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Knowledge Attitude and Practices Among Self Medication Users in A Rural Area of Bhopal

National Journal of Community Medicine, 2016
Introduction: Self medication is an important health issue specially in developing country like India. Practicing self-medication for drugs like antibiotics might lead to drug resistance; and hence, there needs to be a check on these practices ...
Umesh Sinha, Garima Namdev
doaj  

A comparative evaluation of the perception of self-medication among medical students of a tertiary care teaching medical college and hospital – A cross-sectional study

National Journal of Physiology, Pharmacy and Pharmacology, 2019
Background: Self-medication is the use of medicine without medical supervision to treat one’s own ailment. It is most prevalent in developing countries like India and has the potential to do good as it is cost effective for treating common illness and ...
Triveni Manchu, Meenakshi Lella, Susmitha Vemu, Sowmya Deepthi Chavla   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Health Information Online [PDF]

, 2005
Presents findings from a survey conducted in November 2004. Looks at the growth in Internet use for finding health information; the specific health topics that are most frequently searched; and trends that are likely to influence online health ...
Susannah Fox
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source