Results 131 to 140 of about 20,464,759 (310)

Transcatheter versus surgical aortic valve replacement in low-risk patients with severe aortic stenosis: a systematic review and meta-analysis. [PDF]

BMC Cardiovasc Disord
Fadl ZA, Darwish MY, Moawad WM, Aboelmagd NO, Fadl GA, El Husseny MWA, Abdelsattar NK, Taha TAA.   +7 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Patient satisfaction with advanced practice physiotherapy internationally: A systematic mixed studies review. [PDF]

PLoS One
Davis C, Noblet T, Breach J, Mistry J, Maddigan K, Kowalski K, Rushton A.   +6 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

From phase 1 to approval: lymphoma's long road. [PDF]

Blood Adv
Hertzberg M.
europepmc   +1 more source

D2.2 Draft Overall 5G RAN Design

, 2016
This deliverable provides the consolidated preliminary view of the METIS-II partners on the 5 th generation (5G) radio access network (RAN) design at a mid-point of the project. The overall 5G RAN is envisaged to operate over a wide range of spectrum bands comprising of heterogeneous spectrum usage scenarios.
Arnold, Paul, Bayer, Nico, Belschner, Jakob, Rosowski, Thomas, Zimmermann, Gerd, Ericson, Mårten, Da Silva, Icaro Leonardo, Bulakci, Ömer, Kaloxylos, Alexandros, Spapis, Panagiotis, Ibrahim, Ahmed M., Yang, Yang, Singh, Shubhranshu, Celik, Haris, Monserrat del Río, Jose Francisco   +14 more
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Analytical Quality by Design-Guided Optimisation and Validation of a Short-Run Stability-Indicating Reverse-Phase Ultra-Fast Liquid Chromatography (RP-UFLC) Method for the Quantitation of Nonivamide. [PDF]

Biomed Chromatogr
Mahlangu P, Poka MS, Makoni PA, Witika BA.   +3 more
europepmc   +1 more source

Overall infrastructure design

D6.1 will document the overall infrastructure design for the European Navigational Hazard Infrastructure, reporting on the work done in task 6.1.
openaire   +1 more source